Triggering Oocyte Maturation in POSEIDON Group 3 and 4 Poor Responders Using Double Trigger or HCG Trigger

Phase 2Not Yet RecruitingNCT07569289

Bedaya Hospital164 enrolled

Overview

The aim of this randomized controlled study is to compare the efficacy of double trigger protocol \[ the co-administration of GnRH agonist with HCG ( 38 - 39 and 35 - 36 h prior to ovum pick-up, respectively \] with HCG in triggering ovulation in patients with expected poor response to ovarian stimulation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

164

Conditions

Infertility

Interventions

Double triggerDRUG

Triptorelin (0.2 mg/S.C ) and HCG (10000 IU/I.M) are administered 38 to 39 h and 35 to 36 h prior to ovum pick-up., respectively.

HCG triggerDRUG

HCG (10000 IU/I.M) is administered 35 to 36 h prior to ovum pick-up.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * POSEIDON group 3 and 4 * GnRH antagonist IVF cycle Exclusion Criteria: * Hypogonadotrophic hypogonadism * Endometriosis * History of recurrent abortion

Locations (1)

Bedaya Hospital

Giza, Giza Governorate, Egypt

Outcomes

Primary Outcomes

Metaphase-II oocytes rate

Number of MII oocyte/ number of cumulus oocyte complex

Time frame: Ten to fifteen days after starting ovarian stimulation

Secondary Outcomes

Clinical pregnancy rate

Presence of intrauterine gestational sac detected by transvaginal ultrasound

Time frame: Five weeks after embryo transfer

Ongoing pregnancy Rate

Pregnancies continued beyond 20 weeks gestation

Time frame: Eighteen weeks after embryo transfer

Central Contacts

Usama M Fouda, Prof.

CONTACT

+201095401375 umfrfouda@yahoo.com

Data from ClinicalTrials.gov

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