The aim of this randomized controlled study is to compare the efficacy of a modified dual trigger protocol \[a single bolos of HCG combined with two successive doses of a GnRH agonist \] with HCG \[a single bolos administered 36 hours before oocyte retrieval \] in triggering ovulation in normo-responders undergoing ovarian stimulation using the antagonist protocol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
196
HCG (10000 IU /IM) and triptorelin (0.2 mg/S.C) are administered 36 hours before ovum pickup . Moreover, 0.1mg of triptorelin is administered 24 h prior to ovum pick-up.
HCG (10000 IU/IM ) is administered 36 hours before ovum pickup.
Bedaya Hospital
Giza, Giza Governorate, Egypt
Metaphase-II oocytes rate
Number of MII oocyte/ number of cumulus oocyte complex
Time frame: Ten to fifteen days after starting ovarian stimulation
Clinical pregnancy rate
Presence of intrauterine gestational sac detected by transvaginal ultrasound
Time frame: Five weeks after embryo transfer
Ongoing pregnancy Rate
Pregnancies continued beyond 20 weeks gestation
Time frame: Eighteen weeks after embryo transfer
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