The aim of this randomized controlled study is to compare the efficacy of three successive doses of a GnRH agonist ( administered 36 , 24 and 12 hours before oocyte retrieval ) with a single dose of a GnRH agonist ( administered 36 hours before oocyte retrieval ) in triggering ovulation in hyper-responders
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
190
GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) is administered 36 hours before ovum pickup. Two additional doses of triptorelin ( 0.1 mg / S.C ) are administered subcutaneously 12 and 24 hours after the first dose of GnRH agonist.
GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) is administered 36 hours before ovum pickup.
Bedaya Hospital
Giza, Egypt
Metaphase-II oocytes rate
Number of MII oocyte/ number of cumulus oocyte complex
Time frame: Ten to fifteen days after starting ovarian stimulation
Clinical pregnancy rate
Presence of intrauterine gestational sac detected by transvaginal ultrasound
Time frame: Five weeks after embryo transfer
Ongoing pregnancy Rate
Pregnancies continued beyond 20 weeks gestation
Time frame: Eighteen weeks after embryo transfer
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