Exososmes in Atrophic Scars Management

Zagazig University12 enrolled

Overview

Lay Summary (Simple Explanation) Atrophic scars are depressed scars that form when the skin does not heal properly, commonly seen after acne or injuries. These scars can affect appearance and confidence, and current treatments may not always give satisfactory results. This study aims to evaluate a new treatment using exosomes, which are tiny particles naturally released by cells that help in skin repair and regeneration. Researchers will compare the effect of injecting exosomes directly into scars versus injecting a simple saltwater solution (saline), which serves as a control. Participants will be randomly assigned to receive either exosome injections or saline injections. Neither the patient nor the evaluator may know which treatment is given, to ensure fair comparison. The goal is to determine whether exosomes can safely and effectively improve the appearance and texture of atrophic scars.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Atrophic Scar

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Age \>18 years * Either gender * Scars of any duration * Multiple scars at one side or both sides of the face. * Patients are willing to sign written informed consent statements before beginning treatment. Exclusion Criteria: * Pregnant females. * Patients with one scar. * Hypersensitivity to any of the used treatments. * Patient with infection at the site of the scar. * Patients with unrealistic expectations. * Patient refusing to sign on the consent.

Outcomes

Primary Outcomes

modified Manchester Scar Scale

Scar appearance was assessed using the Modified Manchester Scar Scale. The Modified Manchester Scar Scale ranges from 4 to 24, with lower scores indicating better scar appearance and higher scores indicating worse scar appearance

Time frame: 3 months after 4 biweekly sessions

Secondary Outcomes

Scar thickness measurement in millimetres by Ultrasound examination

Scar characteristics, including scar thickness and echogenicity, will be assessed using high-frequency ultrasound examination. Scar thickness will be measured in millimeters, and changes from baseline to follow-up will be summarized. Higher scar thickness values indicate greater scar tissue thickness