The purpose of this study is assess the incidence of postoperative atrial fibrillation (POAF) within one week of surgery in patients who receive pre-surgical stellate ganglion blockade with liposomal bupivacaine, compared to those receiving a saline placebo, using continuous electrocardiographic monitoring via wearable ECG devices.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
450
Patients undergoing isolated coronary artery bypass grafting will receive a stellate ganglion block using liposomal bupivacaine prior to surgery
Patients undergoing isolated coronary artery bypass grafting will receive a saline placebo injection to the stellate ganglion prior to surgery
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Incidence of new-onset postoperative atrial fibrillation (POAF) within one week of isolated coronary artery bypass grafting (CABG) surgery
Total number of patients to experience postoperative atrial fibrillation within one week of CABG surgery.
Time frame: 1 week
Total duration of postoperative atrial fibrillation (POAF) episodes within the first postoperative week
Duration of postoperative atrial fibrillation episodes will assessed via continuous ECG monitoring and reported in minutes
Time frame: 1 week
Number of patients with successful stellate ganglion blockade
Success rate of the stellate ganglion blockade is defined as a ≥1.0°C increase in ipsilateral hand skin temperature from baseline and/or a reduction in skin sympathetic nerve activity (SKNA) as measured by noninvasive surface recordings pre- and post-block.
Time frame: 1 week
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