This study is testing a new medicine that might help treat people with type 2 diabetes. The purpose of the study is to see if the new study medicine is safe and how well is tolerated by the body. There will be two groups of participants in this study: healthy participants and participants with type 2 diabetes. Participant will either get study medicine (NNC1679-0001) or placebo (a treatment that has no active medicine in it). NNC1679-0001 is a new experimental medicine that doctors cannot prescribe yet. Which treatment the participant gets is decided by chance. Participant will get one dose which will be injected into the area around abdomen (belly) by the medical staff.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
58
NNC1679-0001 will be administered subcutaneously.
Placebo will be administered subcutaneously.
Medical University of Graz
Graz, Austria
RECRUITINGNumber of Treatment-Emergency Adverse Events (TEAEs)
Measured in events.
Time frame: From dosing (day 1) upto week 34
Number of TEAEs
Measured in events.
Time frame: From dosing (day 1) until V15a/V15b (week 26)
Number of hypoglycaemic episodes
Measured in episodes.
Time frame: From dosing (day 1) upto week 34
AUC: The area under the NNC1679-0001 plasma concentration-time curve from time zero to the last measurable concentration after a single dose
Measured in hours\*nanograms per milliliter (hour × ng/mL).
Time frame: From dosing (day 1) upto day 3 or day 15
Cmax: The maximum concentration of NNC1679-0001 in plasma after a single dose
Measured in nanograms per milliliter (ng/mL).
Time frame: From dosing (day 1) upto day 3 or day 15
tmax: The time from dosing to maximum plasma concentration of NNC1679-0001 after a single dose
Measured in hours.
Time frame: From dosing (day 1) upto day 3 or day 15
t1/2: Terminal half-life for NNC1679-0001 after a single dose
Measured in hours.
Time frame: From dosing (day 1) upto day 3 or day 15
CLR: Renal clearance of NNC1679-0001 after a single dose
Measured in liter per hours (L/hours).
Time frame: From dosing (day 1) upto day 3
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