Transcranial Magnetic Stimulation as a Treatment for Postpartum Obsessive Compulsive Disorder

N/ANot Yet RecruitingNCT07571187

Butler Hospital15 enrolled

Overview

The goal of this clinical trial is to learn if accelerated transcranial magnetic stimulation (TMS) is a feasible treatment for obsessive compulsive disorder that worsens or starts within 12 months of childbirth. The main questions it aims to answer are: Is TMS a tolerable and acceptable treatment for postpartum women with OCD? Does TMS improve OCD symptoms in postpartum women? Does TMS change connectivity between areas of the brain involved in OCD? Participants will: 1. Receive 50 sessions of a type of TMS called continuous theta burst stimulation (cTBS) over the course of two weeks. 2. Complete clinical assessments before and after TMS, as well as at 1 and 3 months post-treatment 3. Undergo functional magnetic resonance imaging (fMRI) of the brain before and after TMS

This study will involve a small open-label, single arm feasibility trial of an accelerated cTBS protocol to the right orbitofrontal cortex (rOFC) in postpartum OCD. Following initial screening and consent, all participants (n=15) will undergo a baseline clinical assessment that will record OCD severity and symptom profiles, concurrent anxiety and depressive disorders, contraindications to TMS and medical history. Participants will then undergo a baseline functional magnetic resonance imaging (fMRI) scan at the Brown MRI Research Facility. This will be followed by 10 days of cTBS (5 sessions daily) to the rOFC during which symptoms and adverse effects will be monitored daily using a standardized checklist. At the end of day 5, participants will be asked to repeat some of the self-report clinical symptom measures included in the baseline clinical assessment. At the end of the cTBS protocol, participants will repeat a full clinical assessment, obtain an endpoint fMRI scan, and complete an acceptability questionnaire. Follow-up clinical assessments will be completed at 1-month and 3-months post-treatment either in person or virtually to assess the durability of responses. These data will be used as initial evidence of feasibility for a larger pilot study.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 18-45 2. Diagnosis of OCD defined by DSM-V criteria with problematic symptoms in the 12 months following childbirth 3. YBOCS ≥16 4. Either currently taking OCD medications at a stable dose for 8 weeks or unmedicated 5. Concurrent psychotherapy (exposure and response prevention therapy) will be allowed if it was initiated 8 weeks or more before study entry and continues regularly throughout the trial 6. Ability to read, write and understand English sufficiently well to complete study procedures and provide informed consent. Exclusion Criteria: 1. Past history of a primary psychotic or bipolar disorder 2. Current acute suicidality or significantly elevated risk of suicide as determined by the investigators 3. Personal history of moderate traumatic brain injury, epilepsy, or other clinically significant neurological illness except tic disorders 4. A history of pre-eclampsia during the most recent pregnancy if the patient is less than 8 weeks postpartum 5. Current, moderate to severe alcohol or illicit substance use disorder in the last 3 months, determined by clinical assessment 6. Women who are currently pregnant. All participants will be asked to use a reasonable birth control method throughout the study period (barrier, oral contraceptives, etc.). We will not administer pregnancy tests. 7. current psychotic symptoms 8. A current seizure disorder 9. active severe major depressive episode as indicated on the Edinburgh Postnatal Depression Scale (greater than or equal to 19).

Outcomes

Primary Outcomes

Yale-Brown Obsessive Compulsive Scale (YBOCS)

A 10-item scale that measures OCD symptom severity

Time frame: From enrollment to the end of treatment at two weeks, and from enrollment to 1 and 3 months post-treatment.

Secondary Outcomes

The Edinburgh Postnatal Depression Scale (EPDS)

A 10-item self-report measure of postnatal depression

Time frame: From enrollment to end of treatment at 2 weeks, and from enrollment to 1 and 3 months post-treatment

The Perinatal Anxiety Screening Scale (PASS)

A 31-item self-report measure of perinatal anxiety symptoms

Time frame: From enrollment to end of treatment at 2 weeks, and from enrollment to 1 and 3 months post-treatment

The Generalized Anxiety Disorder-7 Scale (GAD-7)

A 7-item self-report measure of anxiety

Time frame: From enrollment to end of treatment at 2 weeks, and from enrollment to 1 and 3 months post-treatment

Functional Connectivity on Magnetic Resonance Imaging (fMRI)

Changes in functional connectivity between the right orbitofontal cortex and the broader "OCD connectome"

Time frame: From enrollment to end of treatment at two weeks

Transcranial Magnetic Stimulation as a Treatment for Postpartum Obsessive Compulsive Disorder

Overview

Conditions

Interventions

Eligibility

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts