The purpose of this study is to investigate how immunosuppression treatment affects measurements of active collagen deposition using \[68Ga\]CBP8 positron emission tomography (PET) and tissue injury using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in individuals with non-idiopathic pulmonary fibrosis interstitial lung disease (non-IPF ILD).
15 different subjects with non-IPF ILD starting immunosuppression treatment for their underlying ILD will be enrolled. Participants will undergo \[68Ga\]CBP8 PET and DCE-MRI prior to and 12 weeks after treatment initiation to determine the effects of immunosuppressive treatment on PET measurements of collagen deposition and selected DCE-MRI-derived measurements.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
15
Participants will receive a single intravenous injection of up to 350 MBq of \[68Ga\]CBP8
Participants will receive a single intravenous injection of 0.05 mmol/kg gadoterate meglumine during DCE-MRI
Massachusetts General Hospital
Boston, Massachusetts, United States
RECRUITINGChange in SUVmax25 over the entire lungs
Changes in lung collagen uptake will be measured using the PET probe \[68\]Ga-CBP8. Measurements will be made using the mean of the upper quartile of standardized uptake values (SUVmax25). Primary \[68Ga\]CBP8-PET outcome.
Time frame: From baseline to 12 weeks
Change in the rate of contrast washin (kwashin) over the entire lungs
Changes in rate of contrast washin will be measured using dynamic-contrast enhanced MRI. Primary DCE-MRI outcomes.
Time frame: From baseline to 12 weeks
Change in SUVmean over the entire lungs
Changes in lung collagen uptake will be measured using the PET probe \[68\]Ga-CBP8. Measurements will be made using the mean standardized uptake value (SUVmean).
Time frame: From baseline to 12 weeks
Change in SUVmax over the entire lungs
Changes in lung collagen uptake will be measured using the PET probe \[68\]Ga-CBP8. Measurements will be made using the max standardized uptake value (SUVmax).
Time frame: From baseline to 12 weeks
Change in peak enhancement over the entire lungs
Changes in peak enhancement will be measured using dynamic-contrast enhanced MRI
Time frame: From baseline to 12 weeks
Change in time to peak over the entire lungs
Changes in time to peak will be measured using dynamic-contrast enhanced MRI
Time frame: From baseline to 12 weeks
Change in the area under the curve at 60 seconds (AUC60) over the entire lungs
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Changes in the area under the curve at 60 seconds will be measured using dynamic-contrast enhanced MRI
Time frame: From baseline to 12 weeks
Change in the rate of contrast washout (kwashout) over the entire lungs
Changes in the rate of contrast washout will be measured using dynamic-contrast enhanced MRI.
Time frame: From baseline to 12 weeks