The purpose of this study is to determine the absorption, metabolism and excretion of \[14C\]-JNT-517 and to characterize and determine the metabolites present in plasma, urine, and feces in healthy male participants following a single oral administration.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
8
Suspension
Fortrea Clinical Research Unit Inc.
Madison, Wisconsin, United States
Total Radioactivity Recovery (fet1-t2) in Urine and Feces
Time frame: Up to Day 9
Relative Amounts Of Radioactivity Excreted in Urine and Feces
Time frame: Up to Day 9
Area Under the Concentration-time Curve From Time Zero to Infinity (AUC0-∞) of [14C]-JNT-517 And Its Metabolites in Plasma
Time frame: Up to Day 9
Area Under The Concentration-Time Curve From Time Zero to The Time Of The Last Quantifiable Concentration (AUC0-tlast) of [14C]-JNT-517 And Its Metabolites in Plasma
Time frame: Up to Day 9
Maximum Plasma Concentration (Cmax) of [14C]-JNT-517 And Its Metabolites in Plasma
Time frame: Up to Day 9
Time to Reach Maximum (Peak) Observed Plasma Concentration (Tmax) of [14C]-JNT-517 And Its Metabolites in Plasma
Time frame: Up to Day 9
Apparent Terminal Elimination Half-Life (t½) of [14C]-JNT-517 And Its Metabolites in Plasma
Time frame: Up to Day 9
AUC₀-∞ of Total Radioactivity in Plasma And Whole Blood
Time frame: Up to Day 9
AUC₀-tlast of Total Radioactivity in Plasma And Whole Blood
Time frame: Up to Day 9
Cmax of Total Radioactivity in Plasma and Whole Blood
Time frame: Up to Day 9
Tmax of Total Radioactivity in Plasma and Whole Blood
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Time frame: Up to Day 9
t½ of Total Radioactivity in Plasma and Whole Blood
Time frame: Up to Day 9
Number of Participants With Treatment-Emergent Adverse Events (TEAEs)
Time frame: Up to Day 9
Number of Participants With Clinically Significant Changes in Clinical Laboratory Test Parameters
Time frame: Up to Day 9
Number of Participants With Clinically Significant Changes in 12-lead Electrocardiogram (ECG) Parameters
Time frame: Up to Day 9