This clinical trial aims to investigate whether transcranial electrical stimulation (tDCS) combined with transcranial magnetic stimulation(TMS) has an impact on the cognitive and motor functions of stroke patients, and to evaluate the safety of this protocol. The main objective is to answer the following question: Can electromagnetic combined stimulation of the left Dorsolateral prefrontal lobe(DLPFC) improve the performance of working memory, motor function and cognitively motor dual tasks in stroke patients? What is its mechanism of action? Participants will undergo a combined real or sham electromagnetic stimulation of 20 minutes of tDCS and 40 seconds of TMS once a day for 7 days. Researchers will compare the effects of real stimulation with sham stimulation to see if the real stimulation can bring better results to patients. Clinical evaluations (cognitive and motor scales) and functional Near-Infrared Spectroscopy(fNIRS) were conducted before and after stimulation to record relevant brain activities
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
24
occupational therapy 1 hour a day for 7 days
real 20 minutes of tDCS once a day for 7 days
sham 20 minutes of tDCS once a day for 7 days
40 seconds of real TMS once a day for 7 days
40 seconds of sham TMS once a day for 7 days
Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
n-back task accuracy rate
n-back task record accuracy rate
Time frame: Baseline and 7-days
n-back task reaction time
n-back task record reaction time
Time frame: Baseline and 7-days
functional connectivity during n-back task
n-back task with fNIRS to record Oxy-Hb concentration
Time frame: Baseline and 7-days
Verbal fluency test（VFT）accuracy rate
VFT task record accuracy rate
Time frame: Baseline and 7-days
Verbal fluency test（VFT）reaction time
VFT task record reaction time
Time frame: Baseline and 7-days
functional connectivity during Verbal fluency test（VFT）
VFT task with fNIRS to record Oxy-Hb concentration
Time frame: Baseline and 7-days
Montreal Cognitive Assessment(MoCA)
MoCA scale(score 0-30, the higher score means the better function)
Time frame: Baseline and 7-days
isokinetic muscle strength test
isokinetic muscle strength test of knee
Time frame: Baseline and 7-days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.