Effect of vitk2 on Atopic Dermatitis Pediatrics Patients

October 6 University100 enrolled

Overview

investigate the effectiveness and safety of adding vitamin K2 at a dose of 45 mg/day for 12 weeks to conventional therapy for paediatric patients with moderate to severe atopic dermatitis according to SCORAD score

This was a multicentre, prospective, blind randomized. patients are randomized to either receive their conventional therapy alone or by adding vitamin k2 for 12 weeks. The primary outcome was to evaluate the impact of vitamin K2 on the severity of atopic dermatitis, as assessed by the SCORAD score at 12 weeks compared to baseline.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

100

Conditions

Atopic Dermatitis

Interventions

vit k2DIETARY_SUPPLEMENT

Vitamin K2 is a fat-soluble vitamin essential for blood clotting, bone health, and heart health, found in animal products and fermented foods.

PlaceboOTHER

placebo

Eligibility

Sex: ALLMin age: 6 YearsMax age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients aged 6-12 years * moderate to severe AD according to SCORAD score Exclusion Criteria: * other cutaneous allergic diseases (urticaria, angioedema, anaphylaxis, contact dermatitis). * primary immunodeficiency (PID) with cutaneous allergic manifestations.

Locations (1)

October 6 University

Giza, Egypt

Outcomes

Primary Outcomes

to evaluate the impact of vitamin K2 on the severity of atopic dermatitis, as assessed by the SCORAD score

Time frame: at baseline and after 3months

Secondary Outcomes

Examination of the skin for eczema distribution, extent and intensity and Complete systemic examination for different forms of allergic disorder.

Time frame: 3months

Janus kinase (JAK)

Time frame: Measured at baseline and after three months

Serum total IgE

Time frame: At baseline and after three months

IL-13

Time frame: at baseline and after three months

lipid profile

Time frame: at baseline and after three months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.