Effect of Self-assembly Peptide With or Without Laser on Remineralization of Initial Carious

Delta University for Science and Technology30 enrolled

Overview

This study aimed to asses the effect of different remineralizing agents on the initial carious lesions at diff rant after immediately after treatment (as baseline), six months and one year. Objectives: Evaluation of reminralizing effect of: 1. Self- assembly peptide 2. Nano-hydroxy apitite gel 3. CPP-ACP varnish With or without laser treatment at three times intervals, immediately after treatment (as baseline), six months and one year

This study aimed to asses the effect of different remineralizing agents ( self-assembly peptide, nanohydroxy apitite gel and CPP-ACP varnish) with or without laser surface treatment on the initial carious lesions after immediately after treatment (as baseline), six months and one year using detecting device.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Carious Lesion Caries; Initial

Interventions

ER-CR LaserRADIATION

ER-CR laser was applied for 10 sec in non-contact mode, at a distance of two mm, with pulse duration of 60 microsecond at four-Watt energy (80% water 60% air), 50 Hz energy.

Without ER-CR LaserOTHER

ER-Cr laser was not used before the application of reminaralizing agents

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: between 18 and 35 years of age, active carious (ICDAS), had received conventional manual periodontal therapy, had no systemic diseases or concomitant medication affecting salivary flow. \- Exclusion Criteria:Participant in another trial, non-carious lesion (enamel hypoplasia and dental fluorosis), Presence of abnormal oral, medical, or mental condition. Participants who had evidence of reduced salivary flow or significant tooth wear, also who had allergy to MI paste. \-

Locations (1)

Mohamed Galal Elkholy

Cairo, Egypt

Outcomes

Primary Outcomes

Quantitative assessment of initial carious activity in numerical value using DIAGNOdent ( laser fluorescence detecting device )

Assessment of initial carious activity after using three different reminralizing agents with \\ without laser pre treatment using DIAGNOdent laser fluorescence detecting device

Time frame: 1 year

Data from ClinicalTrials.gov

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