Association Between Hypomagnesemia and Coagulopathy in Sepsis

Ain Shams University150 enrolled

Overview

This study aimed to investigate the association between hypomagnesemia and coagulopathy in patients with sepsis, with a focus on evaluating whether low serum magnesium levels are independently linked to the development of disseminated intravascular coagulation during intensive care unit admission.

Sepsis is a life-threatening condition characterized by organ dysfunction resulting from a dysregulated host response to infection. It remains a major global cause of morbidity and mortality in intensive care units (ICUs). Hypomagnesemia, commonly observed in ICU patients, has been associated with poor outcomes, including increased need for mechanical ventilation and extended ICU stays. Its immunomodulatory and vasoprotective functions make it a key factor in sepsis pathophysiology.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Hypomagnesemia Coagulopathy Sepsis

Interventions

Serum magnesium concentrationDIAGNOSTIC_TEST

Serum magnesium concentration test was measured.

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 20 years at the time of Intensive Care Unit (ICU) admission. * Diagnosis of sepsis based on Sepsis-3 criteria \[confirmed or suspected infection + Sequential Organ Failure Assessment (SOFA) score ≥ 2\]. * Admission to the ICU during the study period. * Serum magnesium level measured at ICU admission. * Coagulation parameters \[e.g., platelet count, Prothrombin Time/International Normalized Ratio (PT-INR), fibrinogen, D-dimer\] within 24 hours of ICU admission. * Complete clinical and laboratory data for calculating the International Society on Thrombosis and Haemostasis (ISTH) overt Disseminated Intravascular Coagulation (DIC) score. Exclusion Criteria: * Patients with missing data on serum magnesium or coagulation markers at ICU admission. * ICU admissions due to non-infectious causes (e.g., trauma, elective surgery without infection). * Presence of pre-existing coagulopathy or hematologic malignancy affecting baseline coagulation (e.g., leukemia, hemophilia). * Known history of magnesium supplementation prior to ICU admission. * End-stage renal disease on dialysis, which may significantly alter magnesium handling. * Pregnant women, due to altered magnesium physiology. * Patients transferred from or to another hospital within 24 hours of ICU admission (incomplete follow-up).

Locations (1)

Ain Shams University

Cairo, Egypt

Outcomes

Primary Outcomes

Incidence of disseminated intravascular coagulation

Incidence of disseminated intravascular coagulation (DIC) was recorded. International Society on Thrombosis and Haemostasis (ISTH) overt DIC score, a diagnostic system developed by the International Society on Thrombosis and Haemostasis. A score ≥ 5 will be used to define overt DIC, indicating systemic coagulation activation in the presence of a high-risk clinical condition

Time frame: 5 days post-procedure

Secondary Outcomes

Incidence of Intensive Care Unit mortality

Incidence of Intensive Care Unit (ICU) mortality was recorded.

Time frame: 5 days post-procedure

Length of Intensive Care Unit stay

Length of Intensive Care Unit stay was recorded.

Time frame: 5 days post-procedure

Requirement for vasopressor therapy

Requirement for vasopressor therapy was recorded.

Time frame: 5 days post-procedure

Data from ClinicalTrials.gov

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