Vision Rehabilitation Training With Multimodal Feedback in Central Vision Loss

Change in Saccadic Latency

Time in milliseconds from target appearance to saccade initiation, measured using binocular eye tracking. Faster latencies indicate improved oculomotor response.

Time frame: At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )

Change in Smooth Pursuit Gain

Ratio of eye velocity to target velocity during smooth pursuit tasks (optimal gain = 1.0). Higher gain values indicate better pursuit tracking accuracy.

Time frame: At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )

Change in Number of Catch-up Saccades During Pursuit

Mean number of corrective saccades per trial during smooth pursuit tasks. Fewer catch-up saccades indicate smoother, more accurate pursuit performance.

Time frame: At First study visit - Baseline, At each training visit (week 1, week 2, week 3, week 4, week 5, and post training (week 11 )

Change in Contrast Sensitivity Function

Area under the log contrast sensitivity function (AULCSF) measured using adaptive Gabor presentations during eye movement tasks. Higher values indicate better contrast sensitivity.

Time frame: Baseline, Post-training (Week 6)

Change in Fixation Stability

Area of the bivariate contour ellipse at 95% confidence interval of fixation positions during stationary target fixation tasks, measured in square degrees. Smaller ellipse area indicates more stable fixation.

Time frame: Baseline, Post-training (Week 6)

Change in Vision Related Quality of Life

Baseline, Post-training (Week 6)

Time frame: At First study visit - Baseline, at last training session - week 5, and post training (week 11 )