This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive care unit (ICU) length of stay (LOS).
This large national cohort study, including over 500,000 patients, aims to evaluate the association between time to initiation of continuous renal replacement therapy (CRRT) and intensive care unit (ICU) length of stay (LOS). The investigators hypothesize that earlier start of CRRT is associated with shorter length of stay among critically ill patients. CRRT is seen as a costly intervention, and after studies failing to demonstrate a mortality benefit from earlier initiation, the trend is to push, or postpone the start of CRRT. In Sweden the additional cost of CRRT amounts to around 5000 SEK, approximately 500 dollars/euros per 24 hours. However, the 24-hour cost of staying in the ICU is around 58000 SEK or 5800 dollars/euros.
Study Type
OBSERVATIONAL
Enrollment
500,000
We are evaluting early vs late initiation of CRRT
Intensive care unit (ICU) length of stay (LOS) measured in hours
Hours from baseline, i.e. ICU admission (time=0) to ICU discharge (time=0+hours in ICU)
Time frame: ICU LOS during the study period, from admission to discharge, average 168 hours (one week)
Mortality
Days from baseline, i.e. ICU admission to 30, 90,180 and 365 day mortality
Time frame: ONE-YEAR Mortality post admission
Mechanical ventilation
Hours from baseline, i.e. start of ventilation (time=0) until end of ventilation, hours
Time frame: Time on mechanical ventilation during the study period, average one week, but up to ICU discharge
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