The purpose of this study is to evaluate coronary artery and peripheral vein vascular endothelial profiles in patients with ischemia with non-obstructive coronary arteries (INOCA) who undergo coronary function testing (CFT). The aims are: (1) Evaluate coronary artery endothelial profiles and associations with coronary microvascular dysfunction (CMD) in INOCA. (2) Assess brachial vein endothelial cell profiles in patients with INOCA and associations with CMD, and (3) Characterize relationships between endothelial signatures and anginal symptoms, functional status, and physical activity at baseline and 1-year follow-up.
Study Type
OBSERVATIONAL
Enrollment
250
Participant will undergo invasive coronary angiography as clinically indicated (standard of care).
Endothelial cells will be obtained from clinical coronary guidewires after retrieval from the guide catheter.
Wearable activity monitoring device that measures physical activity based on the number of steps per day. The device also tracks sleep efficiency (exploratory) through a proprietary algorithm, and other health metrics. Daily step count and heart rate are recorded on the wearable device.
Participants will undergo invasive coronary function testing as clinically indicated (standard of care).
NYU Langone Health
New York, New York, United States
Change in Seattle Angina Questionnaire (SAQ) score
The Seattle Angina Questionnaire (SAQ) scores range from 0 to 100 for all five domains (Physical Limitations, Angina Stability, Angina Frequency, Treatment Satisfaction, and Quality of Life), with higher scores indicating better health status, fewer limitations, and less frequent angina. A 10-point change in score is typically considered clinically significant.
Time frame: Baseline, 1 year follow up
Change in Duke Activity Status Index (DASI) score
The DASI is a 12-item self-report questionnaire used to assess a patient's functional capacity. Scores range from 0 to 58.2, with higher scores indicating better functional capacity.
Time frame: Baseline, 1 year follow up
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