This observational study aims to describe the histopathological features of granulation tissue (GT) found in residual periodontal pockets at the time of surgical intervention, after completion of the first two steps of periodontal therapy, according to EFP guidelines (Sanz et al., 2020). A secondary objective was to analyze GT characteristics in relation to clinical outcomes (e.g., defect type, probing depth reduction and clinical attachment gain) in order to identify possible statistical associations between tissue patterns and clinical improvements.
The study was conducted at the Section of Periodontology, Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Italy. Ethical approval was obtained from the Sapienza University Ethics Committee (6997 / 23-01-2023). Granulation tissue samples were collected during standard periodontal surgery from tissues that would normally be removed, without any additional intervention for the enrolled patients.
Study Type
OBSERVATIONAL
Enrollment
21
Sapienza University of Rome, Department of Oral and Maxillofacial Sciences, Section of Periodontology
Roma, Roma, Italy
Histopathological characterization of granulation tissue components
Semiquantitative analysis (0-4 scale) of epithelial, subepithelial connective, deep connective, inflammatory, and osseous components in GT samples.
Time frame: At time of surgery
Correlation between GT composition and clinical outcomes
Assessed through statistical association analysis with probing depth reduction, clinical attachment gain and defect type
Time frame: At time of surgery
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