D-RSBI Versus RSBI for Predicting Weaning Success in COPD Patients

Sohag University100 enrolled

Overview

This prospective observational cohort study aims to compare the predictive accuracy of diaphragmatic rapid shallow breathing index (D-RSBI) versus traditional rapid shallow breathing index (RSBI) for predicting weaning success from invasive mechanical ventilation in COPD patients. Diaphragmatic ultrasound measurements will be performed during spontaneous breathing trials, and patients will be followed for 72 hours after extubation to assess weaning outcomes.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Chronic Obstructive Pulmonary Disease (COPD)Mechanical Ventilator Weaning

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Mechanically ventilated COPD patients fulfilling standard weaning readiness criteria. * Invasive mechanical ventilation for more than 24 hours before spontaneous breathing trial. * Hemodynamically stable without significant vasopressor support. * Adequate oxygenation with FiO2 ≤ 0.5 and PEEP ≤ 8 cmH2O . * Preserved mental status and ability to initiate spontaneous breathing. * Successful tolerance of spontaneous breathing trial conducted on CPAP mode with pressure support ≤ 8 cmH2O. Exclusion Criteria: * Refusal of consent * Neuromuscular disease, phrenic nerve palsy, or diaphragmatic paralysis. * Large pneumothorax or pathology interfering with ultrasound assessment. * Terminal extubation. * Recent major thoracic surgery. * Poor sonographic window despite repeated attempts.

Locations (1)

Sohag University Hospital

Sohag, Sohag Governorate, Egypt

RECRUITING

Outcomes

Primary Outcomes

AUROC of D-RSBI for prediction of successful weaning

Area under the receiver operating characteristic curve (AUROC) of diaphragmatic rapid shallow breathing index (D-RSBI) for predicting successful weaning within 72 hours after extubation in mechanically ventilated COPD patients.

Time frame: Within 72 hours after extubation

Secondary Outcomes

AUROC of conventional RSBI for prediction of successful weaning.

Area under the receiver operating characteristic curve (AUROC) of conventional rapid shallow breathing index (RSBI) for predicting successful weaning within 72 hours after extubation in mechanically ventilated COPD patients.

Time frame: Within 72 hours after extubation

Difference between AUROC values of D-RSBI and conventional RSBI

Comparison between AUROC values of D-RSBI and conventional RSBI for prediction of successful weaning.

Time frame: Within 72 hours after extubation

Central Contacts

Ahmed Atef Mohamed, MBBCh

CONTACT

+201006973892 ahmed_ateff_post@med.sohag.edu.eg

Data from ClinicalTrials.gov

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