Gingival recession (GR) is a term that describes the displacement of the gingival margin apical to the cemento-enamel junction (CEJ) of a tooth. The gold standard of GR treatment is surgical coverage through coronally advanced flap with subepithelial connective tissue graft (CAF+SCTG) (3). But, the need for a non-invasive technique for managing GR has not been frequently addressed. Phenytoin (PHT), used as an anti-seizure medication, has an established side effect of causing drug-influenced gingival enlargement. Its stimulatory effects on soft tissue metabolism suggested PHT to be tested topically for its effectiveness in wound healing. However, none of the previous studies that investigated topical phenytoin has assessed gingival recession; except for a case series.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
30
Phenytoin 1% paste
placebo paste
Clinical Attachment loss
measured by Periodontal probe (distance from cemento-enamel junction to base of the pocket)
Time frame: 3 months
gingival recession
Measured by periodontal probe (distance from gingival margin to cemento-enamel junction)
Time frame: 3 months
probing depth
Measured by periodontal probe (distance from gingival margin to base of the pocket)
Time frame: 3 months
gingival thickness
Measured by periodontal probe (is the probe visible during probing or not? Yes/No)
Time frame: 3 months
Keratinized tissue width
Measured by periodontal probe
Time frame: 3 months
dentin hypersensitivity
assessed by asking the patient if they feel sensitivity as binary outcome (yeas/no) and if yes, it is assessed by VAS
Time frame: 3 months
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