HERO-UTUC: Intravesical RC48 After RNU for HER2+ UTUC

Inclusion Criteria: 1. Age ≥18 years. 2. Histologically or radiologically suspected UTUC planned for RNU 3. HER2-positive tumor defined as IHC 1+, 2+, or 3+ on preoperative or surgical specimen testing. 4. ECOG performance status 0-1. 5. No prior or concomitant bladder urothelial carcinoma within 5 years. 6. Adequate hematologic, hepatic, and renal function. 7. Ability to comply with protocol-required surveillance. 8. Written informed consent. - Exclusion Criteria: 1.Evidence of metastatic disease before enrollment. 2.Prior treatment with disitamab vedotin. 3.Prior intravesical anti-cancer therapy within 12 months. 4.Active uncontrolled infection. 5.Pregnancy or breastfeeding. 6.Severe uncontrolled cardiovascular, pulmonary, hepatic, or systemic disease. 7.Known hypersensitivity to study drug components. 8.Any condition that, in the investigator's judgment, would compromise participation or interpretation. \-