A Study of BW-20507 in Chinese Healthy Subjects and Subjects With Chronic Hepatitis B

Inclusion Criteria: Ia： * healthy male or female participants Ib： * Males or females aged 18 to 65 years (inclusive) at the time of informed consent * Body mass index (BMI) ≥18 and ≤28 kg/m2, with body weight \>50 kg (male) or 45 kg (female) * Serum hepatitis B surface antigen (HBsAg) positive for ≥6 months at screening Exclusion Criteria: Ia * unhealthy male or female participants * Any clinically significant chronic diseases of cardiovascular, respiratory, endocrine, immune, renal, gastrointestinal, skin, hematologic, neuropsychiatric, or other systems (excluding chronic HBV infection), or laboratory test abnormal (unrelated to chronic HBV infection) that, in the opinion of the Investigator, makes the subject unsuitable for participation in the study * Any other clinically significant chronic liver disorders in addition to chronic HBV infection, including but not limited to: alcoholic liver disease, moderate or above fatty liver, autoimmune liver disease, hereditary metabolic liver disease, etc. * Significant hepatic fibrosis or hepatic cirrhosis, i.e., FibroScan \>9.0 kPa within 1 month prior to screening, or liver paracentesis pathology showing advanced hepatic fibrosis (Metavir F3) or hepatic cirrhosis (Metavir F4) within 1 year prior to screening