This study will evaluate the clinical efficacy of injectable alloplastic bone grafts in terms of radiography and histology in order to preserve tooth sockets following extraction. Methodology: Twenty new extraction sockets from twenty surgically extracted non-restorable mandibular molar teeth will be used in this clinical investigation.
Using computer randomization (http://www.randomlists.com), the 20 extraction sockets will be split into two equal groups (n=10) at random. Ten sockets (the experimental group) will undergo socket preservation using injectable bone substitute biomaterial. To permit normal physiological healing, the remaining 10 sockets (control group) will left unfilled. Clinical examination will be carried out after 2 days, 1 week, 2 weeks, 1 month, and 4 months, while after 4 months, radiographic measurements of bone dimension changes were carried out, and the histological inspection will be carried out three months after the removal of the tooth.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Ten extraction sockets will undergo socket preservation using injectable bone substitute biomaterial following atraumatic tooth extraction and socket curettage.
Ten extraction sockets will be left unfilled after atraumatic extraction to allow normal physiological healing.
Change in buccolingual ridge width assessed by CBCT
Buccolingual ridge width will be measured radiographically using CBCT immediately post-extraction (baseline) and after 4 months
Time frame: Baseline and 4 months
Bone density assessed by CBCT
Bone density of the extraction socket will be evaluated radiographically using CBCT gray values immediately post-extraction (baseline) and after 4 months.
Time frame: Baseline and 4 months
Percentage of newly formed bone assessed histomorphometrically
The percentage of newly formed bone will be evaluated histomorphometrically using hematoxylin and eosin staining during implant placement.
Time frame: 3 months
Percentage of residual graft material
Residual graft material percentage will be assessed histomorphometrically using hematoxylin and eosin staining during implant placement.
Time frame: 3 months
Percentage of connective tissue
Connective tissue percentage will be assessed histomorphometrically using hematoxylin and eosin staining during implant placement.
Time frame: 3 months
Mucosal healing
Clinical mucosal healing will be assessed by the presence or absence of infection, swelling, and adverse tissue reaction during follow-up visits.
Time frame: Up to 4 months
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