COMPARISON OF DEXMEDETOMIDINE AND NORMAL SALINE IN NEBULIZATION TO BLUNT HEMODYNAMIC RESPONSE

N/AActive Not RecruitingNCT07596004

Shaheed Mohtarma Benazir Bhutto Institue of Trauma66 enrolled

Overview

BLUNTING OF HEMODYNAMIC RESPONSE WILL BE OBSERVED IN PATIENTS NEBULISED WITH DEXMEDETOMIDINE AND NORMAL SALINE.

ONE GROUP OF PTS WILL BE NEBULISED WITH DEXMEDETOMIDINE AND OTHER WITH NORMAL SALINE AND WILL BE OBSERVED DURING AND AFTER INTUBATION FOR ATTENUATION OF HEMODYNAMIC RESPONSE FOR LYRANGOSCOPY AND ENDOTRACHEAL INTUBATION

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

HEMODYNAMIC RESPONSETO LYRANGOSCOPY AND ENDOTRACHEAL INTUBATION

Interventions

DexmeditomidineDRUG

dexmeditomidine 1mcg/kg diluted in 5ml 0.9% sodium chloride, administered via nebulizer over 5 minutes, 30 minutes prior to anesthetic induction .

Normal Saline (0.9% Sodium Chloride)DRUG

normal saline 5 ml administered via nebulizer over 5 minutes, 30 minutes prior to anesthetic induction.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 18-60 years 2. Either gender 3. ASA Physical Status I and II 4. Mallampati airway class I and II 5. BMI 18-30 kg/m2 6. Patients undergoing elective surgery under general anesthesia Exclusion Criteria: 1. Patient refusal or lack of consent 2. Anticipated difficult airway 3. Intubation attempt lasting more than 15 seconds 4. Pregnancy 5. Uncontrolled hypertension, cardiac, pulmonary, hepatic, or cerebral events 6. Known allergy to dexmedetomidine or study drugs

Locations (1)

SMBBIT

Karachi, Sindh, Pakistan

Outcomes

Primary Outcomes

change in mean artirial pressure and heart rate after lyrangoscopy and intubation

hemodynamic stress response measured as change in mean arterial pressure and heart rate from baseline. MAP and HR will be recorded at baseline T0, 1 minute post intubation T1 ans 3 minute post intubation T3. Significant stress response is defined as rise in MAP nad HR more than 10% of baseline at 3 minutes post intubation.

Time frame: baseline, 1 minute and 3 minute post intubation

Data from ClinicalTrials.gov

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