Endoscopic retrograde cholangiopancreatography (ERCP) is a key procedure for managing biliopancreatic diseases, although it is associated with complications such as post-ERCP pancreatitis. This study assessed the efficacy of a prophylactic protocol combining rectal indomethacin with aggressive hydration to reduce the incidence of post-ERCP pancreatitis and serum amylase and lipase levels.
A randomized controlled trial was conducted with 60 patients undergoing ERCP at a secondary-care teaching public hospital. Patients were divided into two groups: With and without prophylaxis. Differences in post-ERCP pancreatitis incidence and pancreatic enzyme levels before and after the procedure were analyzed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
60
The gold standard for treating diseases affecting the biliopancreatic ducts, choledocholithiasis being the most common indication, for which sphincterotomy is the most frequently performed procedure.
Chihuahua City General Hospital "Dr. Salvador Zubirán Anchondo"
Chihuahua City, Chihuahua, Mexico
Post-ERCP pancreatitis
Pancreas inflammation after the ERCP procedure
Time frame: From the end of the ERCP procedure through 24 hours
Post-ERCP pancreatitis
Pancreas inflammation due to the ERCP procedure
Time frame: Ocurring in the first 24 hours posterior to the ERCP
Post-ERCP Pancreatic enzyme elevation
Elevation of the amylase and/or lipase after the ERCP procedure
Time frame: Ocurring in the first 24 hours posterior to the ERCP
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