This is a retrospective study encompassing all \[18F\]FET PET scans performed at our centre. By analysing both static and dynamic scans, conducting in-depth kinetic modelling, and comparing quantitative parameters across different tumour types and clinical contexts, the study aims to determine the true diagnostic value of \[18F\]FET PET in everyday clinical practice. The ultimate goal is to identify imaging biomarkers useful for improving tumour characterisation and distinguishing recurrence from post-treatment changes, thereby strengthening the role of \[18F\]FET PET in modern neuro-oncology.
Study Type
OBSERVATIONAL
Enrollment
69
Primary outcome
Diagnostic accuracy of \[18F\]FET PET (static and dynamic PET/CT or PET/MR) in differentiating tumor recurrence from treatment-related changes, using a composite reference standard including histopathological data (when available) and clinical-radiological follow-up.
Time frame: Retrospective analysis of data acquired up to December 31, 2025.
Secondary Outcome Measure
Quantification and clinical utility of static \[18F\]FET PET parameters in tumor characterization.
Time frame: Up to December 31, 2025.
Diagnostic Outcome Measure
Diagnostic performance of quantitative \[18F\]FET PET parameters in differentiating tumor types and clinical categories (high-grade vs low-grade gliomas, primary brain tumors vs metastases, and histological subtypes).
Time frame: Up to December 31, 2025.
Quantitative outcome
Correlation of quantitative \[18F\]FET PET metrics with imaging biomarkers from other modalities and added value of kinetic modeling.
Time frame: Up to December 31, 2025.
Secondary Outcome Measure
Quantification and clinical utility of dynamic \[18F\]FET PET parameters in tumor characterization
Time frame: Up to December 31, 2025
Secondary Outcome Measure
Quantification and clinical utility of kinetic and parametric \[18F\]FET PET in tumor characterization
Time frame: Up to December 31, 2025.
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