Researchers are looking for new ways to treat certain types of advanced and/or metastatic solid tumors. The main goal of this study is to learn about the safety of different doses of MK-4884 and if participants tolerate them.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
120
Oral Administration
NEXT Oncology ( Site 0151)
San Antonio, Texas, United States
RECRUITINGPrincess Margaret Cancer Centre ( Site 0004)
Toronto, Ontario, Canada
RECRUITINGNumber of Participants Who Experience One or More Dose-Limiting Toxicities (DLTs)
DLT is defined as the occurrence of protocol-specified toxicities, unless clearly related to disease progression or intercurrent illness.
Time frame: Up to approximately 21 days
Number of Participants Who Experience an Adverse Event (AE)
An AE is any untoward medical occurrence in a participant, temporally associated with the use of study treatment, whether or not considered related to the study treatment. The number of participants with experience an AE will be reported.
Time frame: Up to approximately 39 months
Number of Participants Who Discontinue Study Treatment Due to an AE
An AE is any untoward medical occurrence in a participant, temporally associated with the use of study treatment, whether or not considered related to the study treatment. The number of participants who discontinued study treatment due to an AE will be reported.
Time frame: Up to approximately 39 months
Area Under the Concentration-Time Curve (AUC) of MK-4884
Blood samples will be collected to determine the AUC of MK-4884 in plasma.
Time frame: At designated timepoints (up to approximately 15 days)
Maximum Plasma Concentration (Cmax) of MK-4884
Blood samples will be collected to determine the Cmax of MK-4884 in plasma.
Time frame: At designated timepoints (up to approximately 15 days)
Trough Plasma Concentration (Ctrough) of MK-4884
Blood samples will be collected to determine the Ctrough of MK-4884 in plasma.
Time frame: At designated timepoints (up to approximately 39 months)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Centre Hospitalier de l'Université de Montréal-Unit for Innovative Therapies ( Site 0002)
Montreal, Quebec, Canada
RECRUITINGRambam Health Care Campus ( Site 0051)
Haifa, Israel
RECRUITINGRabin Medical Center ( Site 0053)
Petah Tikva, Israel
RECRUITINGNational Cancer Center Hospital ( Site 0201)
Chūō, Tokyo, Japan
RECRUITINGCantonal Hospital St.Gallen ( Site 0101)
Sankt Gallen, Canton of St. Gallen, Switzerland
RECRUITINGCHUV (centre hospitalier universitaire vaudois) ( Site 0103)
Lausanne, Canton of Vaud, Switzerland
RECRUITINGOspedale Regionale Bellinzona e Valli ( Site 0104)
Bellinzona, Canton Ticino, Switzerland
RECRUITINGTime to Maximum Plasma Concentration (Tmax) of MK-4884
Blood samples will be collected to determine the Tmax of MK-4884 in plasma.
Time frame: At designated timepoints (up to approximately 15 days)
Apparent Terminal Half-life (t½) of MK-4884
Blood samples will be collected to determine the t1/2 of MK-4884 in plasma.
Time frame: At designated timepoints (up to approximately 15 days)