This study will evaluate the pharmacokinetic effects of acute and chronic dosing of a hemp-based cannabidiol (CBD) topical lotion with low levels of delta-9-tetrahydrocannabinol (THC) in a sanitized and controlled environment.
Participants (N = 6) will complete an 7-day residential study using a high CBD/low D9-THC lotion. The lotion is applied to the participants' upper arms four times daily in a sanitized and controlled procedure that eliminates the potential for specimen contamination. Oral fluid (OF) is collected before and after application (six samples/day); blood and urine are collected once/day. On discharge day, participants provide an intentionally contaminated OF sample. Participants return after a 7-day washout to provide 4 additional OF specimens, one "clean" and three more intentionally contaminated samples over a two-hour course.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
20
Behavioral Pharmacology Research Unit
Baltimore, Maryland, United States
Change in concentration of oral fluid cannabinoids
Concentration of cannabinoids will be measured in oral fluid (unit of measurement: nanograms/mL)
Time frame: Days 1-7 and Day 14
Change in concentration of blood cannabinoids
Concentration of cannabinoids will be measured in blood (unit of measurement: nanograms/mL)
Time frame: Days 1-7 and Day 14
Change concentration of urine cannabinoids
Concentration of cannabinoids will be measured in urine (unit of measurement: nanograms/mL)
Time frame: Days 1-7 and Day 14
Change in the number of total minutes of sleep
Change in sleep patterns. Change in the number of total minutes of sleep will be measured via vital monitoring and sleep profiling
Time frame: Days 1-7
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.