This retrospective cohort study evaluated transfusion practices and outcomes in 137 severely injured trauma patients requiring massive transfusion at a Level I trauma center (2020-2025). This study analyzed balanced transfusion ratios, whole blood (WB) use, thromboelastography (TEG), and adjunctive hemostatic therapies to determine their impact on 30-day mortality and other clinical outcomes.
Study Type
OBSERVATIONAL
Enrollment
137
University of Florida Health Trauma One Center
Gainesville, Florida, United States
30-day all cause mortality
Time frame: 30 days post-transfusion
in-hospital mortality
Time frame: From date of hospital admission until date of death, assessed up to 60 months
ICU length of stay
Time frame: from date of ICU admission until date of ICU discharge, assessed up to 60 months
Hospital length of stay
Time frame: from admission till discharge or death
Ventilator-free days
Time frame: Within 28 days post-ventilator use
Acute kidney injury
Time frame: Increase in serum creatinine by ≥0.3 mg/dL within 48 hours, or Increase in serum creatinine to ≥1.5 times baseline within 7 days, or Urine output <0.5 mL/kg/hour for 6 hours.
thromboembolic events
deep vein thrombosis, pulmonary embolism, stroke
Time frame: from date of admission up till date of discharge, assessed up to 60 months
Number of participants with multiorgan failure
Multiorgan failure (MOF) was defined as dysfunction or failure of two or more organ systems as assessed by the Sequential Organ Failure Assessment (SOFA) score.
Time frame: From date of hospital admission until date of documented organ failure, assessed unto 60 months
Transfusion related complications
Transfusion related acute lung injury, Transfusion associated circulatory overload
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Time frame: Within 6 hours of transfusion