Phase I Randomized Controlled Trial of Functional Resistance Training in Older Cancer Survivors: The ACES Trial

Timed Up and Go (TUG) test

Physical assessment of mobility by evaluating the time that it takes a person to rise from a chair, walk 3 meters, turn around, and return and sit in the chair. Faster times indicate better mobility

Time frame: Baseline, 16 weeks

Physical Performance Battery (PPB) test

Physical assessment of three timed tests (five repeated chair stands, standing balance, and usual pace gait speed over 4 meters), scored on a scale of 0 (unable) to 4 (completes without difficulty), based on quartiles of performance, then scores are summed, where higher scores indicate better physical functioning.

Time frame: Baseline, 16 weeks

Patient Reported Outcomes Measurement Information System (PROMIS) FACIT-Fatigue Short Form 13a

Self-report on 13 questions about fatigue in the past seven days, on a scale ranging from 1 (not at all) to 5 (very much), where higher total scores indicate more fatigue.

Time frame: Baseline, 16 weeks

PROMIS Sleep Disturbance Short Form 8a

Self-report on 8 questions about symptoms of sleep disturbance in the past seven days, on a scale ranging from 1 (not at all) to 5 (very much), where higher total scores indicate greater sleep disturbance.

Time frame: Baseline, 16 weeks

PROMIS Depression Short Form 4a

Self-report on 4 questions on depressive symptoms in the past seven days, on a scale ranging from 1 (never) to 5 (always), where higher total scores indicate greater depressive symptoms.

Time frame: Baseline, 16 weeks

PROMIS Physical Function Short Form 10a

Self-report on 10 questions of physical capability and instrumental activities of daily living, on a scale from 1 (unable to do) to 5 (without any difficulty), where higher scores indicate greater physical function.

Time frame: Baseline, 16 weeks

PROMIS Pain Intensity Short Form 10a

Self-report on 3 questions about pain intensity over the past seven days, and current pain intensity, on a scale from 1 (had no pain) to 5 (very severe), where higher scores indicate greater pain intensity.

Time frame: Baseline, 16 weeks

PROMIS Cognition Short Form 8a

Self-report on 8 questions about perceived cognitive function (i.e., memory, concentration, verbal fluency, and mental acuity) over the past seven days, on a scale from 1 (very often \[several times a day\]) to 5 (never), where higher scores indicate better cognitive function.

Time frame: Baseline, 16 weeks

PROMIS Anxiety Short Form 4a

Self-report on 4 questions about fear, anxious misery, hyperarousal, and somatic symptoms related to arousal, on a scale from 1 (never) to 5 (always), where higher scores indicate worse anxiety-related symptoms.

Time frame: Baseline, 16 weeks

EuroQoL-5 Dimensions (EQ-5D) Questionnaire

Self-report on health-related quality of life, with two components. 1) Five dimensions related to health (i.e., mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), each of which is assigned a level from 1 (no problems) to 5 (extreme problems) and organized into a five-digit number representing the respondent's health state (e.g., 11235). Each 5-digit number corresponds to a health profile. 2) A visual analogue scale from 0 (worst imaginable health) to 100 (best imaginable health), where higher scores indicate better self-perceived health status.

Time frame: Baseline, 16 weeks

European Organisation for Research and Treatment of Cancer QoL Questionnaire-Core 30 (QLQC-30)

Self-report on 30 questions about cancer-specific quality of life for five functional scales (physical, cognitive, emotional, social functioning, and role functioning) and one global health scale, on either a 4- (1=not at all to 4=very much) or 7-point (1=very poor to 7=excellent) Likert scale, where higher function-oriented scores indicate better functioning, and higher symptom-oriented scores indicate worse symptom severity. Transformed scores range from 0-100, where higher scores indicate better functioning.

Time frame: Baseline, 16 weeks

Nottingham Scale for Extended Activities of Daily Living (NEADL)

Self-report on 22 questions about independence in instrumental activities of daily living (IADL; i.e., functional status) over four domains of activity (mobility, leisure, kitchen, and domestic tasks), on a scale from 0 (not at all) to 3 (on my own), where higher scores indicate more independence.

Time frame: Baseline, 16 weeks

Life Space Questionnaire (LSQ)

Self-report on nine questions about movement across different spatial zones (i.e., community mobility) over the preceding three days, scored from 1 (yes) to 0 (no), where higher scores indicate greater mobility.

Time frame: Baseline, 16 weeks

Late Life Function and Disability instrument (LLFDI)

Self-report on 16 questions about physical function and disability in two domains (frequency and limitation). The frequency scale is from 1 (never) to 5 (very often), where higher scores indicate more frequent participation in social and life activities. The limitation scale is from 1 (completely) to 5 (not at all), where higher scores indicate less limitations in completing activities.

Time frame: Baseline, 16 weeks

Montreal Cognitive Assessment (MoCA)

Researcher-administered test of 11 questions used to screen for cognitive impairment, on a scale of 0-30 points, where higher scores (26+) indicate normal cognition, and lower scores indicate mild (18-15), moderate (10-17), or severe (\<10) cognitive impairment.

Time frame: Baseline, 16 weeks

Adverse Event Prevalence and Attribution [Safety]

Self-report on adverse events (AE) experienced throughout study involvement, as reported on a monthly AE survey; prevalence, severity, and attribution to the intervention will be determined.

Time frame: Monthly over the 16-week intervention period.