The purpose of this study is to evaluate how long a participant keeps taking guselkumab or continues with their treatment plan without stopping (treatment persistence) in participants with moderate to severe Crohn's disease (CD) or ulcerative colitis (UC) in real-world setting. CD and UC are inflammatory bowel diseases, a group of inflammatory conditions of the colon and small intestine.
Study Type
OBSERVATIONAL
Enrollment
35
Medical University Vienna
Vienna, Austria
RECRUITINGPersistence with Guselkumab Treatment
Persistence with guselkumab treatment is defined as time at which the next infusion should have taken place for a participant after their last scheduled infusion. It will be used to measure the guselkumab persistence in participants.
Time frame: Up to Week 96
Number of Participants with Early Responses to Guselkumab Measured Using Bowel Urgency
Number of participants with early responses to guselkumab measured using bowel urgency will be assessed via participant diaries.
Time frame: At Weeks 0 (baseline) 1, 2, 4, 8 and 12
Number of Participants with Early Responses to Guselkumab Measured Using Patient Reported Outcome (PRO-2) Components
Number of participants with early responses to guselkumab will be assessed using PRO-2 components and reported via participant diaries. Measurements captured include stool frequency, rectal bleeding, and abdominal pain.
Time frame: At Weeks 0 (baseline), 1, 2, 4, 8 and 12
Number of Participants Achieving Clinical Response for CD as Measured by Harvey-Bradshaw Index (HBI) Score
HBI score is used to assess disease severity and treatment effectiveness. The HBI consists of a 5-part questionnaire, assessing general wellbeing, abdominal pain, number of liquid stools per day, abdominal mass and complications. Clinical response for CD is defined as the reduction in HBI by greater than or equal to (\>=)3 points from baseline or achieving HBI less than or equal to (\<=) 4.
Time frame: At Weeks 12, 48 and 96
Number of Participants Achieving Clinical Response for Ulcerative Colitis (UC) as Measured by Partial Mayo Score (PMS)
PMS is used to assess disease severity and treatment effectiveness. The PMS comprises 3 categories: rectal bleeding, SF, and physician assessment. These are rated from 0-3 and are totaled to give a total score that ranges from 0-12. Higher score indicates severe disease. Clinical response for UC is defined as the PMS score less than (\<) 4 or \>= 30 percent (%) reduction from baseline.
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Time frame: At Weeks 12, 48 and 96
Number of Participants Achieving Clinical Remission for CD as Measured by HBI Score
HBI score is used to assess disease severity and treatment effectiveness. The HBI consists of a 5-part questionnaire, assessing general wellbeing, abdominal pain, number of liquid stools per day, abdominal mass and complications. Clinical remission for CD is defined as a HBI score \<= 4.
Time frame: At Weeks 12, 48 and 96
Number of Participants Achieving Clinical Remission for UC as Measured by PMS
PMS is used to assess disease severity and treatment effectiveness. The PMS comprises 3 categories: rectal bleeding, SF, and physician assessment. These are rated from 0-3 and are totaled to give a total score that ranges from 0-12. Higher score indicates severe disease. Clinical remission for UC is defined as the PMS score \< 2 and a rectal bleeding subscore of 0.
Time frame: At Weeks 12, 48 and 96
Number of Participants Achieving Corticosteroid-Free Clinical Response for CD
Corticosteroid free clinical response for CD is defined as a HBI score \<= 4 or decrease in HBI \>=3 from baseline and no use of corticosteroids for at least 30 days.
Time frame: At Weeks 12, 48 and 96
Number of Participants Achieving Corticosteroid-Free Clinical Response for UC
Corticosteroid free clinical response for UC is defined as the PMS score \< 4 or \>= 30 % reductions from baseline and no use of corticosteroids for at least 30 days.
Time frame: At Weeks 12, 48 and 96
Number of Participants Achieving Corticosteroid-Free Clinical Remission for CD
Corticosteroid free clinical remission for CD is defined as no use of corticosteroids for at least 30 days and a HBI score \<= 4.
Time frame: At Weeks 12, 48 and 96
Number of Participants Achieving Corticosteroid-Free Clinical Remission for UC
Corticosteroid free clinical remission for UC is defined as no use of corticosteroids for at least 30 day, PMS score \< 2 and a rectal bleeding subscore of 0.
Time frame: At Weeks 12, 48 and 96
Number of Participants Achieving Corticosteroid-Free PRO-2 Remission for CD
Corticosteroid free PRO-2 remission for CD is defined as mean AP score \<=1 and a mean SF score \<=3, and no worsening of AP or SF compared with baseline with no use of steroids for at least 30 days.
Time frame: At Weeks 12, 48 and 96
Number of Participants Achieving Corticosteroid-Free PRO-2 Remission for UC
Corticosteroid free PRO-2 remission for UC is defined as SF subscore of 0 or 1, where the SF subscore has not increased from baseline, and a rectal bleeding subscore of 0 with no use of steroids for at least 30 days.
Time frame: At Weeks 12, 48 and 96
Characteristics of Participants Receiving Guselkumab Treatment: Age
Characteristics of participants (age) receiving guselkumab treatment will be reported.
Time frame: At Baseline
Characteristics of Participants Receiving Guselkumab Treatment: Sex
Characteristics of participants (sex) receiving guselkumab treatment will be reported.
Time frame: At Baseline
Characteristics of Participants Receiving Guselkumab Treatment: Smoking Status and History
Characteristics of participants (smoking status and history) receiving guselkumab treatment will be reported.
Time frame: At Baseline
Characteristics of Participants Receiving Guselkumab Treatment: Height
Characteristics of participants (height) receiving guselkumab treatment will be reported.
Time frame: At Baseline
Characteristics of Participants Receiving Guselkumab Treatment: Weight
Characteristics of participants (weight) receiving guselkumab treatment will be reported.
Time frame: At Baseline
Characteristics of Participants Receiving Guselkumab Treatment: Age at Diagnosis
Characteristics of participants (age at diagnosis) receiving guselkumab treatment will be reported.
Time frame: At Baseline
Characteristics of Participants Receiving Guselkumab Treatment: Disease Duration
Characteristics of participants (disease duration) receiving guselkumab treatment will be reported.
Time frame: At Baseline
Characteristics of Participants Receiving Guselkumab Treatment: Disease Severity At Index
Characteristics of participants (disease severity at index) receiving guselkumab treatment will be reported.
Time frame: At Baseline
Characteristics of Participants Receiving Guselkumab Treatment: Comorbid Diagnoses
Characteristics of participants (comorbid diagnoses) receiving guselkumab treatment will be reported.
Time frame: At Baseline
Characteristics of Participants Receiving Guselkumab Treatment: History of UC/CD
Characteristics of participants (history of UC/CD) receiving guselkumab treatment will be reported.
Time frame: At Baseline
Characteristics of Participants Receiving Guselkumab Treatment: Previous Inflammatory Bowel Disease (IBD) Medication Usage
Characteristics of participants (previous IBD medication use) receiving guselkumab treatment will be reported.
Time frame: At Baseline
Characteristics of Participants Receiving Guselkumab Treatment: Previous IBD-Related Surgeries
Characteristics of participants (Previous IBD-related surgeries) receiving guselkumab treatment will be reported.
Time frame: At Baseline
Number of Participants with Adverse Events (AE)
An adverse event is any untoward medical occurrence in a participant administered a medicinal product based on appropriate medical judgment. An AE does not necessarily have a causal relationship with the treatment.
Time frame: Up to Week 96
Number of Participants with Drug-Related AE
An adverse event is any untoward medical occurrence in a participant administered a medicinal product based on appropriate medical judgment. An AE does not necessarily have a causal relationship with the treatment. An adverse event is considered drug-related if there is at least a reasonable possibility that the study drug contributed to the event.
Time frame: Up to Week 96
Number of Participants with Serious Adverse Events (SAE)
A serious adverse event, is any untoward medical occurrence or any adverse drug reaction that at any dose: results in death, is life threatening (the participant was at risk of death at the time of the event; it does not refer to an event that hypothetically might have caused death if it were more severe), requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity, is a congenital anomaly/birth defect, is a suspected transmission of any infectious agent via a medicinal product and is medically important.
Time frame: Up to Week 96
Number of Participants with Drug-Related SAEs
A serious adverse event is any untoward medical occurrence or any adverse drug reaction that at any dose: results in death, is life threatening (the participant was at risk of death at the time of the event; it does not refer to an event that hypothetically might have caused death if it were more severe), requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity, is a congenital anomaly/birth defect, is a suspected transmission of any infectious agent via a medicinal product and is medically important. An SAE is considered drug-related if there is at least a reasonable possibility that the study drug contributed to the event.
Time frame: Up to Week 96
Number of Participants with C-Reactive Protein (CRP) Normalization
CRP normalization is defined as less than or equal to (\<=) 5 microgram per liter (mg/L) since baseline (among participants with elevated CRP at baseline). C-reactive protein is a marker of inflammation that will be measured by physicians following routine clinical practice.
Time frame: At Weeks 0 (baseline), 4, 12, 48 and 96
Change in CRP Levels
Change in CRP levels since guselkumab initiation will be reported. C-reactive protein is a marker of inflammation that will be measured by physicians following routine clinical practice.
Time frame: At Weeks 4, 12, 48 and 96
Number of Participants with Fecal Calprotectin (fCAL) Normalization
fCAL normalization is defined as percentage of fCAL \<= 250 microgram per gram (mcg/g) since baseline (among participants with calprotectin elevation at baseline). fCAL is a marker of inflammation that will be measured by physicians following routine clinical practice where higher values indicate greater intestinal inflammation.
Time frame: At Weeks 0 (baseline), 4, 12, 48 and 96
Change in fCAL Levels
Change in fCAL levels since guselkumab initiation will be reported. fCAL is a marker of inflammation that will be measured by physicians following routine clinical practice where higher values indicate greater intestinal inflammation.
Time frame: At Weeks 4, 12, 48 and 96
Number of Participants Receiving Concomitant IBD Medications During Guselkumab Treatment
Number of participants receiving concomitant IBD medications during guselkumab treatment will be reported.
Time frame: Up to Week 96
Change from Baseline in Health-Related Quality of life (HR-QoL) as Measured by Bowel Urgency
Change from baseline in HRQoL as measured by bowel urgency will be reported. Bowel urgency from participants will be asked as yes or no.
Time frame: At Weeks 0 (baseline), 4, 8,12, 24, 48, 72, 96
Change from Baseline in HR-QoL of Participants with CD Receiving Guselkumab Treatment as Measured by PRO-2 Components
Change from baseline in HRQoL for CD will be measured by PRO-2 components. The CD PRO-2 consists of 2 items: abdominal pain (AP) and stool frequency (SF). AP is a numeric variable with a score between 0-3 and is self-reported by the participant for the 3 days preceding assessment as 0 (no pain), 1 (mild), 2 (moderate) or 3 (severe pain). SF is also a numeric variable calculated the number of liquid stools a participant has experienced over the past 3 days.
Time frame: At Weeks 0(baseline), 4, 8,12, 24, 48, 72, 96
Change from Baseline in HR-QoL of Participants with UC Receiving Guselkumab Treatment as Measured by PRO-2 Components
Change from baseline in HRQoL for UC will be measured by PRO-2 components. The UC PRO-2 is composed of rectal bleeding and stool frequency. Rectal bleeding is a numeric variable with a score between 0-3 and is self-reported by the participants for the 3 days preceding assessment as 0 (None), 1 (Streaks of blood with stool in less than half of the cases), 2 (Obvious blood with stools in most cases) or 3 (Blood alone passes). SF is also a numeric variable calculated the number of liquid stools a participant has experienced over the past 3 days.
Time frame: At Weeks 0 (baseline), 4, 8,12, 24, 48, 72, 96
Changes from Baseline in HRQoL as Measured by Short Inflammatory Bowel Disease Questionnaire (SIBDQ)
The SIBDQ is a health-related quality of life (HRQoL) tool measuring physical, social, and emotional status in IBD participants. The SIBDQ is a 10-item survey measuring HRQoL over the last 2 weeks (frequency of bowel movement, abdominal cramps, fatigue, lack of energy, worry of surgery, fear of no toilet, ability to relax, irritable, impact on leisure, impact on intimacy). The total score ranges from 10 to 70, where high score indicates better QoL.
Time frame: At Weeks 0 (baseline), 12, 48, 96
Changes from Baseline in HRQoL as Measured by Functional Assessment of Chronic Illness Therapy- Fatigue (FACIT-F) Questionnaire
The FACIT-F scale is a 13-item instrument designed to assess fatigue/tiredness and its impact on daily activities and functioning in chronic diseases. The instrument includes items such as tiredness, weakness, listlessness, lack of energy, and the impact of these feelings on daily functioning over the last 7 days. Scores are numeric and range from 0 to 52 with higher scores indicating less fatigue.
Time frame: At Weeks 0 (baseline), 12, 48, 96
Change from Baseline in Satisfaction with Guselkumab Treatment as per Treatment Satisfaction Questionnaire for Medication (TSQM) Total Score
TSQM-9 is an abbreviated version of the 14-item TSQM, and is a reliable and valid measure to assess treatment satisfaction. It consists of 9 items distributed in the domains: side effects, effectiveness, convenience, and global satisfaction, with scores at each domain ranging from 0 to 100. Here, higher scores indicating greater satisfaction for that domain. A positive change from baseline indicates improvement.
Time frame: At Weeks 0 (baseline), 12, 48, 96
Number of Participants Achieving Endoscopic Response in Participants with CD as Measured by Simple Endoscopy Score-CD (SES-CD)
Endoscopic response defined as 50% improvement from baseline in SES-CD total score, or SES-CD total score \<4. SES-CD score can range from 0 to 56. Higher scores indicating more severe disease.
Time frame: Up to Week 96
Number of Participants Achieving Endoscopic Remission in Participants with CD as Measured by SES-CD
Endoscopic remission is defined as SES-CD total score \<=4 with at least 2 points reduction from baseline and no subscore \>1 in any individual component. SES-CD score can range from 0 to 56. Higher scores indicating more severe disease.
Time frame: Up to Week 96
Number of Participants Achieving Endoscopic Improvement in Participants with UC as Measured by Mayo Score
Endoscopic improvement is defined as Mayo score \<=1. The Mayo Clinic Score is a composite index with total score ranging from 0 to 12. Higher scores indicate worse disease activity.
Time frame: Up to Week 96
Number of Participants Achieving Endoscopic Normalization in Participants with UC as Measured by Mayo Score
Endoscopic normalization is defined as Mayo score =0. The Mayo Clinic Score is a composite index with a total score ranging from 0 to 12. Higher scores indicate worse disease activity.
Time frame: Up to Week 96
Number of Participants Achieving Histological Improvement in Participants with UC
Histological improvement defined as neutrophil infiltration in \<5% of crypts, no crypt destruction, no erosions and ulcerations or granulation tissue according to the Geboes grading system, that is, Geboes score \<=3.1.
Time frame: Up to Week 96
Number of Participants Achieving Histological Remission in Participants with UC
Histological remission is defined as the absence of neutrophils from the mucosa (both lamina propria and epithelium), no crypt destruction, no erosions, ulcerations or granulation tissue according the Geboes grading system, that is, Geboes score \<=2B.0.
Time frame: Up to Week 96
Number of Participants Achieving Intestinal Utrasound (IUS) Response in Participants with CD as Measured by Bowel Wall Thickness (BWT)
IUS response is defined as reduction of BWT of \>=25% or normalization (\<=3 millimeters \[mm\]) of the most affected segment at Weeks 24, 48, 72, 96 in participants with increased BWT (\>3 mm) at baseline (Week 0).
Time frame: At Weeks 0 (baseline), 24, 48, 72 and 96
Number of Participants Achieving IUS (Transmural) Remission in Participants with CD as Measured by BWT
IUS remission is defined as normalization of BWT (\<=3 mm) and vascularity (no signal or short signal in color doppler of the most affected segment) at Weeks 24, 48, 72, 96, in participants with increased BWT (\> 3 mm) at baseline (Week 0).
Time frame: At Weeks 0 (baseline), 24, 48, 72 and 96
Change from Baseline in Number of UC/CD Emergency Room Visits
Change from baseline in the number of emergency room visits for treatment of UC/CD will be reported.
Time frame: At Weeks 0 (baseline), 12, 48, 96
Change from Baseline in Number of UC/CD Hospitalizations
Change from baseline in the number of hospitalizations for treatment of UC/CD will be reported.
Time frame: At Weeks 0 (baseline), 12, 48, 96
Change from Baseline in Number of UC/CD Surgeries
Change from baseline in the number of surgeries for treatment of UC/CD will be reported.
Time frame: At Weeks 0 (baseline), 12, 48, 96