Electrolyte Beverage Combined With Polyethylene Glycol for Colonoscopy Bowel Preparation

Nanfang Hospital, Southern Medical University405 enrolled

Overview

This randomized controlled trial aims to evaluate the effects of different ratios of electrolyte beverage and water combined with polyethylene glycol (PEG) on bowel preparation quality before colonoscopy. Participants undergoing elective colonoscopy will be randomly assigned to one of three bowel preparation regimens: PEG prepared with water only, PEG prepared with a low ratio of electrolyte beverage and water, or PEG prepared with a medium ratio of electrolyte beverage and water. The primary outcome is adequate bowel preparation assessed by the Boston Bowel Preparation Scale (BBPS). Secondary outcomes include bowel preparation completion rate, tolerability, adverse events, repeat colonoscopy rate, adenoma detection rate, and ingestion rhythm characteristics during bowel preparation. This study also aims to explore whether electrolyte beverage-assisted bowel preparation may improve bowel cleansing quality by influencing participants' ingestion rhythm and adherence during PEG intake.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

405

Conditions

Colonoscopy Bowel Preparation Solutions Colorectal Cancer Screening

Interventions

PEG With WaterOTHER

Polyethylene glycol (PEG) prepared with water only for bowel preparation before colonoscopy.

PEG With Low-dose Electrolyte BeverageOTHER

Polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:3 ratio for bowel preparation before colonoscopy.

PEG With Medium-dose Electrolyte BeverageOTHER

Polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:1 ratio for bowel preparation before colonoscopy.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adults aged 18-75 years scheduled to undergo elective colonoscopy * Meet the standard clinical indications for colonoscopy; * Able to understand and comply with the bowel preparation procedure and complete oral polyethylene glycol (PEG) intake as required; * Able to comply with study-related data collection and follow-up; * Provide written informed consent voluntarily. Exclusion Criteria: * Previously diagnosed colorectal cancer, intestinal obstruction, or suspected intestinal obstruction; * Active gastrointestinal bleeding or a definite history of gastrointestinal bleeding within the past 4 weeks (including melena, hematochezia, or hematemesis); * Severe renal insufficiency, decompensated heart failure, significant electrolyte imbalance, or other conditions unsuitable for PEG bowel preparation; * Known allergy to polyethylene glycol or components of the electrolyte beverage used in the study; * Pregnant or breastfeeding women; * Any other condition considered by the investigators to make the participant unsuitable for the study.

Outcomes

Primary Outcomes

Adequate Bowel Preparation Rate

Adequate bowel preparation is defined as a total Boston Bowel Preparation Scale (BBPS) score ≥6 with each colonic segment score ≥2 during colonoscopy.

Time frame: At the time of colonoscopy on Day 1

Secondary Outcomes

Total Boston Bowel Preparation Scale Score

Total Boston Bowel Preparation Scale (BBPS) score assessed during colonoscopy.

Time frame: At the time of colonoscopy on Day 1

Bowel Preparation Completion Rate

Proportion of participants who complete the planned polyethylene glycol bowel preparation within 60 minutes.

Time frame: During bowel preparation within 1 hour before colonoscopy on Day 1

Adverse Event Rate

Incidence of adverse events during bowel preparation, including nausea, vomiting, abdominal distension, abdominal pain, dizziness, and fatigue.