Latent Tuberculosis Infection Screening Using QuantiFERON at Pre-Employment Assessment in Hospital Workers CHu Nice

N/ANot Yet RecruitingNCT07608601

Centre Hospitalier Universitaire de Nice1,185 enrolled

Overview

This retrospective observational single-center study aims to evaluate the medical and occupational relevance of systematic screening for latent tuberculosis infection using QuantiFERON-TB Gold Plus during pre-employment occupational health assessment among hospital workers at the University Hospital of Nice. Data will be collected retrospectively from occupational health medical records, immunology laboratory results and, when necessary, data from specialized follow-up by the tuberculosis control center. The primary objective is to determine the proportion of positive QuantiFERON-TB Gold Plus tests at pre-employment screening. Secondary objectives are to identify factors associated with a positive test, to describe the practical consequences of screening, including chest X-ray, diagnosis of latent tuberculosis infection and initiation of preventive treatment, and to estimate the cost of systematic screening.

Study Type

OBSERVATIONAL

Enrollment

1,185

Conditions

Latent Tuberculosis Infection

Interventions

QuantiFERON-TB Gold PlusDIAGNOSTIC_TEST

Retrospective analysis of QuantiFERON-TB Gold Plus results performed as part of routine pre-employment occupational health screening. No additional diagnostic test or intervention will be performed for the purpose of the study.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Newly recruited hospital workers at the University Hospital of Nice. * Workers who underwent pre-employment occupational health assessment during the study period. * Workers who had a QuantiFERON-TB Gold Plus test performed as part of pre-employment screening. Exclusion Criteria: * Known history of active tuberculosis disease before employment. * Previously known latent tuberculosis infection before employment. * Incomplete or unusable occupational health records. * Indeterminate QuantiFERON-TB Gold Plus results will be included in the descriptive analysis but excluded from comparative analyses of test positivity.

Outcomes

Primary Outcomes

Percentage of positive QuantiFERON-TB Gold Plus tests at pre-employment screening

Percentage of positive QuantiFERON-TB Gold Plus

Time frame: At the inclusion

Secondary Outcomes

Association between risk factors and positive QuantiFERON-TB Gold Plus test

Variables collected included age, sex, country of birth, previous stay in a high tuberculosis-incidence area, prior contact with tuberculosis, immunosuppression status, occupational category, and direct patient contact

Time frame: At the inclusion

Percentage of workers with clinical follow-up after positive QuantiFERON-TB Gold Plus test

Chest X-ray, referral to the tuberculosis control center or specialist consultation, final diagnosis of latent tuberculosis infection and initiation of preventive treatment.

Time frame: From the positive QuantiFERON-TB Gold Plus test to completion of specialist follow-up.