Patients with end-stage renal disease have a high burden of cardiovascular mortality, yet ischemic heart disease is often asymptomatic and difficult to diagnose in this population. Recent data suggest that microvascular coronary dysfunction may contribute significantly to myocardial ischemia in dialysis patients, but its true prevalence remains unknown. This study aims to evaluate microcirculatory coronary impairment in hemodialysis patients using invasive coronary angiography with measurement of coronary flow reserve (CFR), index of microcirculatory resistance (IMR). The study will also describe the clinical and biological characteristics associated with microvascular dysfunction in this population, in order to better understand the mechanisms of uremic cardiomyopathy and improve cardiovascular risk stratification.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SCREENING
Masking
NONE
Enrollment
30
Transthoracic ultrasound at rest
Left to the discretion of the centre: dobutamine echocardiography or myocardial scintigraphy.
Even even if the stress test comes back normal (these tests appear to be less effective at diagnosing microcirculatory abnormalities)
Centre Hospitalier Départemental Vendée
La Roche-sur-Yon, France
Percentage of patients with microcirculatory heart disease (i.e. microvascular dysfunction or microvascular vasospasm) identified during coronary angiography
Time frame: Cardiac examinations to be carried out within 8 to 10 weeks of enrolment
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