Alloplastic Graft vs Xenograft for Horizontal Alveolar Ridge Augmentation

Ege University20 enrolled

Overview

This prospective split-mouth randomized controlled trial compared horizontal alveolar ridge augmentation using alloplastic bone graft versus xenograft, both performed simultaneously with implant placement using the decompression technique in the posterior mandible. Outcomes included postoperative edema, pain, soft tissue healing, and horizontal bone gain at 6 months assessed by CBCT.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Alveolar Bone Loss Edentulous Jaw

Interventions

Alloplastic bone graftDEVICE

Alloplastic bone graft with collagen membrane, simultaneous implant placement with decompression technique

XenograftDEVICE

Xenograft with collagen membrane, simultaneous implant placement with decompression technique

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Bilateral mandibular posterior edentulism with indication for implant-supported rehabilitation * Sufficient vertical bone height but insufficient horizontal bone width for implant placement * No infection at surgical site * Non-smoker * No head-and-neck radiotherapy within 2 years * No uncontrolled systemic disease (controlled systemic conditions with INR \<1.2 acceptable) * Signed informed consent Exclusion Criteria: * No indication for implant-supported prosthesis * Smoker * Active infection at surgical site * Head-and-neck radiotherapy within 2 years * Uncontrolled systemic disease * Allergy to study materials * Pregnancy * Age under 18 * Medications interfering with surgical procedures * History of mandibular fracture * Contraindication to surgery determined by consultation * Psychiatric disorder or inability to communication

Locations (1)

Ege University Faculty of Dentistry

Izmir, Bornova, Turkey (Türkiye)

Outcomes

Primary Outcomes

Horizontal Alveolar Bone Gain

Change in horizontal alveolar bone width measured by CBCT at baseline and 6 months

Time frame: 6 months

Secondary Outcomes

Postoperative Edema

Facial edema assessed by measuring three surface distances (lateral orbital rim to mandibular angle, tragus to oral commissure, tragus to pogonion) at baseline, day 2, and day 7

Time frame: 7 days

Postoperative Pain

Postoperative pain assessed using the Visual Analogue Scale (VAS); score range 0-10; higher scores indicate worse pain. VAS scores recorded daily for 7 days

Time frame: 7 days

Soft Tissue Healing

Wound healing assessed using the Landry wound healing index; score range 1-5; higher scores indicate better healing. Landry wound healing index assessed at postoperative days 2 and 7

Time frame: 7 days

Data from ClinicalTrials.gov

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