Injectable Platelet-Rich Fibrin With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defects

October 6 University40 enrolled

Overview

This study aims to clinically and radiographically evaluate the adjunctive effect of injectable platelet-rich fibrin (i-PRF) used in combination with a minimally invasive non-surgical technique for the regenerative treatment of intrabony periodontal defects.

Periodontitis is a chronic inflammatory disease characterized by the progressive destruction of the periodontal supporting tissues, ultimately leading to tooth loss if left untreated. Optimal periodontal regeneration within intrabony defects depends on the preservation of soft tissues and the maintenance of primary wound closure. Minimally invasive non-surgical periodontal therapy (MINST) has been introduced as a concept aiming to obtain extensive subgingival debridement with minimal tissue trauma. Platelet-rich plasma (PRP) is an autologous blood product which is created through the centrifugation process of whole blood. It is defined as having a platelet concentration above that of normal physiological levels. The platelets present in PRP carry granules containing a significant number of active biomolecules.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Platelet-Rich Fibrin Minimally Invasive Non-Surgical Technique Periodontal Intrabony Defects

Interventions

Minimally invasive non-Surgical techniquePROCEDURE

Patients will receive minimally invasive non-Surgical technique (MINST) alone

Minimally invasive non-Surgical technique + platelet-rich fibrinPROCEDURE

Patients will receive minimally invasive non-Surgical technique (MINST)+ injectable platelet-rich fibrin (i-PRF) injection

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients of both genders \>18 years old, medically free of systemic diseases affecting periodontal regeneration. * Diagnosis of 'periodontitis' stage III (grades B or C). * Single-rooted and multi-rooted vital teeth in either the maxilla or the mandible. * Presence of comparable bilateral two- or three-walled intrabony defects \[probing pocket depth (PPD), \> 5 mm with intrabony defect depth ≥ 3 mm, from the alveolar crest to the defect base, at screening radiograph\] not in a furcation-involved tooth. Exclusion Criteria: * Patients with systemic illness known to affect the outcome of periodontal therapy, including diabetes, immune deficiencies, etc. * Pregnant and lactating women * Current use of any form of tobacco. * Non-surgical periodontal treatment in the past 6 months, or surgical periodontal treatment in the past 12 months. * Degree 2 or 3 mobility of the involved sites.6. * Presence of periapical pathology, acute infection, or subgingival restoration which could interfere with clinical measurements.

Locations (1)

October 6 University

Cairo, Egypt

RECRUITING

Outcomes

Primary Outcomes

Presence of comparable bilateral-walled intrabony defects

Assessment of intrabony defect fill radiographically will be measured using the standardized paralleling technique. Presence of comparable bilateral-walled intrabony defects (PPD, \> 5 mm with intrabony defect depth ≥ 3 mm, from the alveolar crest to the defect base, at screening radiograph) not in a furcation-involved tooth.