This Phase 3, randomized, double-blind, active-controlled study evaluates the efficacy and safety of obicetrapib (OBI) compared to bempedoic acid (BPA) in participants with dyslipidemia at high or very high cardiovascular risk. Participants must have elevated low density lipoprotein cholesterol (LDL-C) levels despite receiving maximally tolerated lipid lowering therapy. The primary objective is to compare the LDL-C lowering effect of OBI (a CETP inhibitor) against BPA at 12 weeks
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
426
Orally, Once Daily
Orally, Once Daily
FutureMeds North Tees
Stockton-on-Tees, United Kingdom
RECRUITINGThe primary efficacy endpoint is the percentage change from baseline to Day 84 in LDL-C in the OBI group compared to the BPA group.
Time frame: 84 days
Percentage change from baseline to Day 84 in non-HDL-C in the OBI group compared to the BPA group
Time frame: 84 days
Percentage change from baseline to Day 84 in HDL-C in the OBI group compared to the BPA group;
Time frame: 84 days
Percentage change from baseline to Day 84 in ApoA1 in the OBI group compared to the BPA group;
Time frame: 84 days
Percentage change from baseline to Day 84 in Lp(a) in the OBI group compared to the BPA group;
Time frame: 84 days
Percentage change from baseline to Day 84 in ApoB in the OBI group compared to the BPA group;
Time frame: 84 days
Percentage change from baseline to Day 84 in TGs in the OBI group compared to the BPA group.
Time frame: 84 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.