The goal of this interventional, non-pharmacological clinical study is to assess microcirculatory dysfunction in patients with thrombotic thrombocytopenic purpura (TTP), both during the acute phase and in remission, compared with the general population. Microcirculatory damage will be defined as the presence of at least one abnormal instrumental finding among brain magnetic resonance imaging (MRI), optical coherence tomography angiography (OCT-A), and nailfold videocapillaroscopy. This is a monocentric, national study including two patient cohorts: Cohort 1: patients enrolled during the acute phase Cohort 2: patients enrolled during remission Participants will be followed for three years with a total of five study visits. Researchers will not test any drug but will perform detailed clinical, laboratory, and instrumental assessments to evaluate microvascular involvement over time. Participants will: * Undergo clinical evaluation, including internal medicine and neurological assessments * Provide blood and urine samples for laboratory analyses * Undergo instrumental examinations such as brain MRI, OCT-A, and nailfold videocapillaroscopy * Receive psychological/neuropsychological evaluations * Attend follow-up visits over a 3-year period (at baseline, 3 months \[cohort 1 only\], 12, 24, and 36 months)
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
79
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
The study is defined as interventional because it includes assessments that are not part of routine clinical practice
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Milano, Italy
Prevalence
Prevalence of microcirculation damage in iTTP patients compared to general population
Time frame: From enrollment to the last visit (after 36 months from Time 0)
Cerebral microcirculation lesions
Evaluate cerebral microcirculation lesions (via brain MRI) in both acute and remission phases of TTP to monitor organ damage progression over time
Time frame: From enrollment to the last visit (after 36 months from Time 0)
Retinal microcirculation changes
Assess retinal microcirculation changes (using OCT and OCT-A) during acute and remission phases of TTP to track organ damage evolution
Time frame: From enrollment to the last visit (after 36 months from Time 0)
Peripheral microcirculation
Analyze peripheral microcirculation (with nailfold videocapillaroscopy) in acute and remission phases to evaluate progression of organ involvement in TTP
Time frame: From enrollment to the last visit (after 36 months from Time 0)
Association between cerebral MRI lesions and cognitive or psychological symptoms
Explore the relationship between cerebral MRI lesions and cognitive or psychological symptoms during TTP remission, assessing symptom progression
Time frame: From enrollment to the last visit (36 months from Time 0)
Modification of preclinical biomarkers
Explore the modification of preclinical biomarkers over time at different stage of the disease
Time frame: From enrollment to the last visit (36 months from Time 0)
Associations between preclinical biomarkers and microcirculatory damage
Identify associations between preclinical biomarkers and microcirculatory damage in both acute and remission phases of TTP to predict risk and progression
Time frame: From enrollment to the last visit (36 months from Time 0)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.