Comparison of Hemodynamic Effects of Bupivacaine in Spinal Anesthesia

Phase 2Not Yet RecruitingNCT07616882

Liaquat National Hospital & Medical College100 enrolled

Overview

To assess hemodynamic changes with hyperbaric bupivacaine with spinal anesthesia

Assesment of hemodynamic changes like heart rate and blood pressure with hyperbaric bupivacaine in spinal anesthesia when given in fractionanted versus bolus dose manner

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

100

Conditions

Hemondynamic Changes in Spinal Anesthesia

Interventions

Spinal Anesthesia (bupivacaine)DRUG

In this group B spinal Anesthesia will be given in one single shot

Spinal Anesthesia (bupivacaine)DRUG

In this intervention spinal Anesthesia of bupivacaine will be given in a fractionated manner that is 2/3 of dose initially and then 1/3 after 90 seconds

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I and II * Adults 18 to 60 years of age of either gender * height from 160 to 182cm and BMI from 15 to 29.9kg/m2 Exclusion Criteria: * ASA III and IV * Refusal of consent * any known renal, hepatic, cardiac or cerebrovascular disease * hypersensitivity to local anaesthetics drug * spinal deformity or any contra indications to spinal anesthesia

Locations (1)

Liaquat National Hospital

Karachi, Sindh, Pakistan

Outcomes

Primary Outcomes

Mean Arterial Pressure

Difference in mean arterial pressure between Group B and Group F

Time frame: Baseline and up to 120 minutes

Secondary Outcomes

Hypotension and bradycardia

Incidence of hypotension and bradycardia after spinal Anesthesia between Group B and Group F

Time frame: Baseline and up to 120 minutes

Requirement of vasopressors

Requirements of vasopressors if mean arterial pressure falls below 60mmHg during the procedure and up to 120 minutes

Time frame: Baseline and up to 120 minutes

Central Contacts

Usama, MBBS

CONTACT

+923008978791 bhurgriusama@gmail.com

Data from ClinicalTrials.gov

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