This randomized crossover study investigated the effects of whole-body cryotherapy (WBC) on isokinetic knee performance following running-induced fatigue in physically active healthy male university students. Participants completed two recovery conditions, WBC and passive rest, on separate days following a standardized treadmill fatigue protocol. Knee extension and flexion strength were assessed using an isokinetic dynamometer at angular velocities of 60°/s and 240°/s. In addition, blood pressure, heart rate, oxygen saturation, and perceived fatigue responses were monitored throughout the recovery period. The study aimed to determine whether WBC improves post-exercise recovery and lower-extremity muscle performance compared with passive rest.
This study was designed to investigate the effects of whole-body cryotherapy (WBC) on recovery and isokinetic muscle performance following exercise-induced fatigue in physically active healthy male university students. Exercise-induced fatigue is associated with reduced muscle force production, impaired performance, and increased injury risk. Various recovery strategies have been used to minimize these negative effects, and WBC has gained increasing attention in sports medicine because of its potential physiological and neuromuscular recovery benefits. The study used a randomized within-subject crossover design in which participants completed two recovery conditions, WBC and passive rest, on separate days following a standardized treadmill-based fatigue protocol. During the WBC condition, participants were exposed to a two-stage cryogenic chamber consisting of an adaptation chamber at -30°C followed by a main chamber at -85°C. Passive rest sessions were performed under the same laboratory conditions without cryotherapy exposure. Primary outcome measures included isokinetic knee extension and flexion performance assessed at angular velocities of 60°/s and 240°/s using an isokinetic dynamometer. Peak torque and body mass-normalized peak torque values were analyzed for both dominant and non-dominant lower extremities. Secondary outcome measures included systolic and diastolic blood pressure, heart rate, oxygen saturation, and perceived fatigue responses measured throughout the recovery period. The aim of the study was to determine whether WBC provides superior recovery effects compared with passive rest following running-induced acute fatigue.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
30
Participants underwent whole-body cryotherapy following a standardized running-induced fatigue protocol. The intervention was performed in a two-stage cryogenic chamber consisting of a 30-second adaptation phase at -30°C followed by a 3-minute exposure at -85°C.
Istanbul University
Istanbul, Istanbul, Turkey (Türkiye)
Peak Torque During Knee Extension and Flexion
Assessment of isokinetic knee extension and flexion peak torque at 60°/s and 240°/s following whole-body cryotherapy and passive rest recovery conditions.
Time frame: Immediately after the 30-minute recovery period
Peak Torque Normalized to Body Mass
Assessment of body mass-normalized peak torque values during isokinetic knee extension and flexion testing at 60°/s and 240°/s.
Time frame: Immediately after the 30-minute recovery period
Heart Rate
Assessment of heart rate responses throughout the recovery period following exercise-induced fatigue.
Time frame: Baseline, immediately after exercise, and every 5 minutes during the 30-minute recovery period
Blood Pressure
Assessment of systolic and diastolic blood pressure responses throughout the recovery period.
Time frame: Baseline, immediately after exercise, and every 5 minutes during the 30-minute recovery period
Oxygen Saturation
Assessment of peripheral oxygen saturation during the recovery period.
Time frame: Baseline, immediately after exercise, and every 5 minutes during the 30-minute recovery period
Perceived Fatigue
Assessment of perceived fatigue using the Borg Rating of Perceived Exertion (RPE) Scale (6-20 points). Scores range from 6 (no exertion) to 20 (maximal exertion), with higher scores indicating greater perceived fatigue and exertion.
Time frame: Immediately after exercise, 5 minutes, and 10 minutes after exercise
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