Proof of Concept Study to Isolate Cosmetic Improvement of Skin Using the Vitro Biopharma Secretome/Exosome Serum

Inclusion Criteria: * Male or female subjects over 30 years of age * Non-smoker * Fitzpatrick scale II-IV * Mild to moderate skin wrinkles or fine lines around the eyes (periorbital) and/or radial cheek * Subject agrees to maintain their weight (i.e. within 5%) by not making any major changes in diet of lifestyle during study * Able to provide written informed consent, understand and willing to comply with study related procedures and follow-up * Willing to undergo facial microneedling treatment * Willing to sign photo release (For study purposes and potential publication) Exclusion Criteria: * Prior trauma, surgical procedure or invasive cosmetic procedure in the area of intended treatment * Fat reduction/removal procedure in or around the area of intended treatment up to 1 year prior to enrollment * Cosmetic injections into the area of intended treatment including botulinum toxin injections up to 6 months prior or filler injections up to 1 year prior to enrollment * Ablative or non-ablative dermal resurfacing procedures within 6 months of screening * Skin tightening procedures on the face within the past 3 months * Currently using prescription facial wrinkle therapies * History of bleeding disorder, or is taking any medication that may increase risk of bruising * Dermatological conditions in the location of the treatment sites that may interfere with treatment * Subject has an active infection * Subject has a known metal allergy * Pre-existing scars, tattoos, birthmarks or other physical features in the area of treatment that may confound the outcome in the investigators opinion * Active implanted device such as pacemaker, defibrillator, drug delivery system * Pregnant or intending to become pregnant * Lactating or has been lactating in the last 6 months * History of coagulopathy, or taking anticoagulants * Taking daily oral aspirin * Immunocompromised or immunosuppressed * Active, chronic or recurrent infection * Hypersensitivity to analgesic agents * History of keloid scar formation * Chronic disease such as diabetes, hepatitis, etc. * Oral corticosteroids or topical steroids in the treatment area * Prescription or over the counter (OTC) medication or cosmetics applied to treatment area containing: retinoids, glycol acid, salicylic acid or any other remedies that might affect the healing process. * Co-morbid condition that could limit ability to participate in the study or comply with follow-up requirements * Untreated drug and/or alcohol abuse * Unable or unwilling to comply with the study requirements * Enrolled in another clinical study or taking any unknown or not Food and Drug Administration (FDA) approved medications * Any other condition or presentation that in the opinion of the Investigator might exclude the subject * Intends to begin any new skin medications in the treatment areas * Intends to change their daily skincare routine before or during the study