The Implementation of Genetic Risk for Colorectal Cancer Screening

N/AEnrolling By InvitationNCT07621757

Endeavor Health100 enrolled

Overview

The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are: 1. How does knowledge of a patient's genetic risk for colorectal cancer affect the uptake of initial screening colonoscopies? 2. How do colonoscopy outcomes compare between genetic risk groups?

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Colorectal Cancer Colorectal Adenoma Colorectal Polyp

Eligibility

Sex: ALLMin age: 45 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: \- Due for initial screening colonoscopy per current guidelines Exclusion Criteria: * Prior colonoscopy * Prior personal history of colorectal cancer or inflammatory bowel disease * Medical contraindications to colonoscopy/sedation

Locations (1)

Endeavor Health

Evanston, Illinois, United States

Outcomes

Primary Outcomes

Number of scheduled colonoscopies in each genetic risk group

Time frame: One year following enrollment

Secondary Outcomes

Number of polyps and/or adenomas found through colonoscopy in each genetic risk group

Time frame: One year following enrollment

Data from ClinicalTrials.gov

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