Comparative Effects of Mediterranean and DASH Diet on Hepatic Function

University of Lahore75 enrolled

Overview

Participants were assigned into three groups Control group recieving general dietary guidelines, Mediterranean diet intervention group DASH dietary intervention group

Written permission was taken from the ethical board for data collection. After taking informed consent from patients in written form, the researcher used self-administered questionnaire or Performa to gather data. NAFLD patients (both genders) of age 25 to 70 years were included. 1. Screening: The participants eligible under inclusion criteria will be enrolled. The baseline data (weight, height, BMI, waist circumference, LFT's, Lipid profile, blood pressure). The target population between 25-70 years were selected. 2. Allocation: The participants were assigned into three groups; control group was given dietary guidelines followed by medication; one group was given Mediterranean diet (T1) and other group was given DASH diet (T2) along with conventional therapy 3. Follow up: The follow up of patient were conducted monthly, all laboratory test (LFT's, Lipid profile, blood pressure) were conducted on 1st and after 8th week. The baseline and post-test study were compared to test hypothesis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

NAFLD (Nonalcoholic Fatty Liver Disease)Hep A

Interventions

Dietary guidelines for fatty liverOTHER

Dietary guidelines for managing fatty liver disease followed by medication for 2 months.

Mediterranean dietOTHER

Mediterranean diet plan consists of vegetables, whole grains, and fruit, extra virgin olive oil, nuts, seeds and legumes.

DASH dietOTHER

DASH diet plan consists of antioxidant foods items i.e. fruits and vegetables lean meat and dairy products (low fat dairy products), nuts, grain.

Eligibility

Sex: ALLMin age: 25 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults (25-70 years) of both genders with BMI (above 25 kg/m2). * Fatty liver patients with mild to moderate values of Alanine Transaminase (ALT) level range from mild to moderate (30-100U/L) * Fatty liver patients having Aspartate Aminotransferase (AST) level range from mild to moderate (200-600 IU/L). * Fatty liver patients having Gamma-Glutamyl Transferase (GGT level range from mild to moderate(120-300 U/L) were included. Exclusion Criteria: * Lactating and pregnant women were not included. * Patients who are using any kind of medicine. * Adults suffering from critical health conditions, including cancer.

Locations (1)

University of Lahore

Lahore, Pakistan

Outcomes

Primary Outcomes

Body Mass Index

Body Mass Index (BMI) was computed by dividing weight in kilograms by the square of height in meters (kg/m2).

Time frame: 60 days

Liver Function Test

The blood test was used to measure the serum concentrations of ALT, AST, and GGT. Following an overnight fast, 10 ml of venous blood was collected from participants both at baseline and post-intervention.

Time frame: 60 days

Data from ClinicalTrials.gov

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