This study evaluated the effects of gac fruit oil supplementation on visual health, sleep quality, depressive symptoms, cognitive function, and brain imaging parameters in adults with sleep disturbance. Participants aged 40 to 65 years were recruited and received gac fruit oil capsules for 30 days. The supplementation protocol consisted of two capsules in the morning and two capsules in the evening each day. Assessments were performed before and after the intervention, including macular pigment measurement, ocular surface disease evaluation, tear film analysis, contrast sensitivity testing, accommodative microfluctuation analysis, optical coherence tomography, the Pittsburgh Sleep Quality Index, a depression scale, the Mini-Mental State Examination, and brain magnetic resonance imaging. The study aimed to explore whether 30 days of gac fruit oil supplementation was associated with changes in visual function, sleep quality, mood-related measures, cognitive function, and brain imaging findings.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
50
Participants took gac fruit oil capsules orally for 30 days. The supplementation protocol consisted of two capsules in the morning and two capsules in the evening each day, for a total of four capsules per day.
Yuanpei University of Medical Technology
Hsinchu, Taiwan
Change in Sleep Quality
Sleep quality was assessed using the Pittsburgh Sleep Quality Index before and after 30 days of gac fruit oil supplementation.
Time frame: Baseline and 30 days
Change in Depressive Symptoms
Depressive symptoms were assessed using a depression scale before and after 30 days of gac fruit oil supplementation.
Time frame: Baseline and 30 days
Change in Macular Pigment Level
Macular pigment level was assessed using a macular pigment screener before and after 30 days of gac fruit oil supplementation.
Time frame: Baseline and 30 days
Change in Ocular Surface Disease Symptoms
Ocular surface disease symptoms were assessed using the Ocular Surface Disease Index before and after 30 days of gac fruit oil supplementation.
Time frame: Baseline and 30 days
Change in Tear Film Parameters
Tear film parameters were assessed using a non-contact ocular surface analyzer before and after 30 days of gac fruit oil supplementation.
Time frame: Baseline and 30 days
Change in Contrast Sensitivity
Contrast sensitivity was assessed using the CVS-1000 contrast sensitivity test before and after 30 days of gac fruit oil supplementation.
Time frame: Baseline and 30 days
Change in Accommodative Microfluctuation
Accommodative microfluctuation was assessed using an accommodative microfluctuation analyzer before and after 30 days of gac fruit oil supplementation.
Time frame: Baseline and 30 days
Change in Retinal Structure
Retinal structure was assessed using optical coherence tomography before and after 30 days of gac fruit oil supplementation.
Time frame: Baseline and 30 days
Change in Cognitive Function
Cognitive function was assessed using the Mini-Mental State Examination before and after 30 days of gac fruit oil supplementation.
Time frame: Baseline and 30 days
Change in Brain Magnetic Resonance Imaging Parameters
Brain magnetic resonance imaging parameters were assessed before and after 30 days of gac fruit oil supplementation.
Time frame: Baseline and 30 days
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