The white blood cells of patients with acute myeloid leukemia that have undergone allogeneic stem cell transplantation will be investigated. These are patient where the leukemia has returned after the transplantation.
The study will investigate biomarkers including humen endogenous retrovirus expression and T cell phenotypic analysis in patients with AML with NPM1 mutations or KMT2A rearrangements. These biomarkers have been previously described: Blood. 2026 Jan 29;147(5):584-601. doi: 10.1182/blood.2025029712. PMID: 41144759
Study Type
OBSERVATIONAL
Enrollment
20
University of Freiburg Mdical Center
Freiburg im Breisgau, Germany
RECRUITINGCorrelative biomarker
HERV expression by AML cells
Time frame: 1 year
Biomarkers will be correlated with survival and leukemia response
The biomarkers HERV, HLA class I and II, T cell phenotype
Time frame: may 2026 till may 2027
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.