The purpose of this research study is to determine whether the use of in-home air filtration to reduce exposure to air pollution benefits health.
Conduct a randomized crossover pilot trial with 66 participants to calculate preliminary effect size estimates to inform a larger crossover efficacy trial: We will: 1) enroll 66 individuals living in low and high traffic areas in Hartford (N=44) and a highly polluted urban areas in Boston Chinatown (N=22); and 2) install full filtration DIYAPs and sham DIYAPs for 30 days each in a randomized crossover trial design with a 14-day wash-out in between; and 3) measure seated and ambulatory BP, administer the SF-12v2, the Trail Making Test Part B, collect blood, and measure both indoor and outdoor PM (in size bins).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
66
Portable air purifiers filter air and reduce exposure to air pollutants, in this case, airborne particulate matter
Air purifiers with filters removed (sham)
Blood pressure
Periferal blood pressure, seated
Time frame: Day 0, 30, 45, and 75
IL-1beta
Blood inflammatory biomarker
Time frame: Day 0, 30, 45, and 75
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