Prehypertension is a clinical condition characterized by systolic blood pressure (SBP) readings between 120 and 139 mmHg and/or diastolic blood pressure (DBP) readings between 80 and 89 mmHg, as per the Joint National Committee (JNC 7) and World Health Organization (WHO) guidelines. Individuals falling within this range do not yet meet the criteria for hypertension but are at a significantly elevated risk of progressing to full-blown hypertension and developing associated cardiovascular diseases such as heart attack and stroke. This stage is considered as a critical window for intervention, as timely and appropriate measures can potentially halt or delay the progression to more severe health issues.
This is a randomized, double-blind, placebo-controlled, parallel-group study to evaluate the effectiveness of 4-week supplementation regimen of 'DOSE for Blood Pressure Shot (DBPS)' in reducing systolic and diastolic blood pressure among prehypertensive adults. DBPS is formulated as a liquid oral supplement specifically designed to support cardiovascular wellbeing. The product is rooted in both preliminary scientific evidence and traditional medicinal practices, which indicate that it may exert blood-pressure lowering effects by influencing vascular tone and modulating inflammatory pathways within the body. The active ingredients in DBPS are believed to help relax blood vessels, improve endothelial function, and reduce systemic inflammation, all of which contribute to healthier blood pressure levels.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
198
DOSE for Blood Pressure Shot (DBPS)-A proprietary oral liquid supplement formulation containing active and inactive ingredients of herbal and natural extracts.
An oral liquid supplement formulation similar to the proprietary formulation but with no active ingredients.
Trimurti Hospital
Varanasi, Uttar Pradesh, India
Jain Clinic
Varanasi, Uttar Pradesh, India
Kashi Medicare
Varanasi, Uttar Pradesh, India
Octavia Hospital
Varanasi, Uttar Pradesh, India
Systolic Blood Pressure
Change from baseline to end of the study (4 weeks) in the readings of Systolic Blood Pressure.
Time frame: Week 0 & Week 4
Diastolic Blood Pressure (DBP)
Change from baseline to end of the study (4 weeks) in the readings of Diastolic Blood Pressure.
Time frame: Week 0 & Week 4
Systolic and Diastolic Blood Pressure (SBP and DBP) as recorded by a twenty- four hour-ambulatory blood pressure monitor (24hr ABPM)
Change from baseline to end of the study (4 weeks) in the readings of Systolic and Diastolic Blood Pressure (SBP and DBP) as recorded by a twenty- four hour-ambulatory blood pressure monitor (24hr ABPM)
Time frame: Week 0 & Week 4
hsCRP level
Change from baseline to end of the study (4 weeks) in the level of hsCRP biomarker in serum.
Time frame: Week 0 & Week 4
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