The Effect of Standard vs. Shorter Filter Lifespan During Continuous Renal Replacement Therapy

Inclusion Criteria: 1. Adult ≥ 18 years 2. Critically ill patients with severe AKI consistent with KDIGO stage 3 and an absolute indication for CRRT 3. Written consent form from the patient or legal representative or authorized representative or emergency inclusion Exclusion Criteria: 1. End-stage kidney disease or chronic dialysis dependence 2. Chronic kidney disease with eGFR\<20ml/min/1.73 m² 3. Prior kidney transplant 4. Prior renal replacement therapy during the index admission before randomization 5. Glomerulonephritis, interstitial nephritis, vasculitis 6. Patients on immunosuppression (above the cushing threshold) 7. Patients with chronic inflammatory diseases (e.g. arthritis, HIV with a CD4 count of \< 0.05 x 10E/l) 8. Do-not resuscitate order 9. Persons with any kind of dependency on the investigator or employed by the sponsor 10. Patients participating in an interventional study involving measures to influence the immune system