Based on the bioholographic theory, this study preliminarily explores the clinical efficacy of hand acupuncture in treating acute exacerbation of bronchial asthma and evaluates its immediate anti-asthmatic effect, so as to provide a new therapeutic strategy for the clinical management of bronchial asthma.
This study adopted a randomized controlled trial design, with patients in the acute exacerbation phase of bronchial asthma as the research subjects. A total of 72 patients who met the inclusion criteria were randomly divided into the acupuncture group and the control group in a 1:1 ratio. The control group received standard Western medicine treatment, while the acupuncture group was given acupuncture treatment based on biological holography theory in addition to the standard Western medicine treatment. The acupoints selected were Kechuan point, New Kechuan point, and Yuji point. The treatment was administered once a day for 20 minutes each time, for 5 consecutive days, with a 3-month follow-up. The therapeutic efficacy of manual acupuncture in treating acute exacerbation of bronchial asthma was evaluated with indicators including symptom and sign scores, pulmonary function, ACT , mMRC , Mini-AQLQ scale, serum interleukin-4 (IL-4), serum eotaxin and specific immunoglobulin E (SIgE). In addition, the underlying therapeutic mechanism was preliminarily explored to formulate a technical protocol for rapid anti-asthma acupuncture, laying a foundation for long-term and objective efficacy evaluation of this therapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
72
The acupoints selected were Kechuan point, New Kechuan point, and Yuji point. The treatment was administered once a day for 20 minutes each time, for 5 consecutive days.
Evaluate and manage in accordance with the Chinese Expert Consensus on Assessment and Management of Acute Exacerbation of Bronchial Asthma issued by the Asthma Group of the Chinese Thoracic Society, Chinese Medical Association in 2018 and the Guidelines for the Prevention and Treatment of Bronchial Asthma (2020 ).
the First Affiliated Hospital of Henan University of Chinese Medicine
Zhengzhou, Henan, China
RECRUITINGPeak Expiratory Flow(PEF)
PEF will be used to assess pulmonary function
Time frame: After treatment on Day 5 and follow-up at 1, 2 and 3 months
Asthma Control Test
The ACT score consists of 5 questions, each scored from 1 to 5 points, with a total score ranging from 5 to 25 points; lower scores indicate more severe symptoms.
Time frame: After treatment on Day 5 and follow-up at 1, 2 and 3 months
Forced expiratory volume in first second/pred（FEV1%pred）
FEV1%pred will be used to assess pulmonary function
Time frame: After treatment on Day 5 and follow-up at 1, 2 and 3 months
Clinical Symptom and Sign Score
It includes six symptoms: cough, expectoration, chest tightness, wheezing, shortness of breath and wheeze. Scores of 0, 3, 6 and 9 are assigned according to the severity of symptoms, with higher scores corresponding to more severe symptoms.
Time frame: After treatment on Day 5 and follow-up at 1, 2 and 3 months
Mini Asthma Quality of Life Questionnaire（Mini-AQLQ)
It consists of 15 questions, each scored on a scale from 1 to 7 based on the severity of symptoms and their degree of impact. A score of 1 indicates no symptoms or no adverse impacts, while a score of 7 stands for severe symptoms or substantial impairment. Lower total scores correspond to a higher quality of life.
Time frame: After treatment on Day 5 and follow-up at 1, 2 and 3 months
modified Medical Research Council (mMRC)
Scores range from 0 to 4 based on the severity of dyspnea, with higher scores indicating more severe symptoms.
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Time frame: After treatment on Day 5 and follow-up at 1, 2 and 3 months
Interleukin 4 (IL-4)
Detect the level of IL-4 in peripheral blood
Time frame: After treatment on Day 5
Eotaxin
Detect the level of Eotaxin in peripheral blood
Time frame: After treatment on Day 5
IgE
Detect the level of IgE in peripheral blood
Time frame: After treatment on Day 5