Intensive Care Outcome Prediction Using Admission Carbohydrate-deficient Transferrin

Medical University of Vienna800 enrolled

Overview

The goal of this observational study is to learn whether hazardous alcohol consumption, measured objectively by carbohydrate-deficient transferrin (CDT) levels at intensive care unit (ICU) admission, is associated with worse outcomes in critically ill patients. The main question it aims to answer is: Do elevated CDT levels at ICU admission predict increased short-term mortality and adverse clinical outcomes in adult non-traumatic ICU patients? Participants admitted to the intensive care unit via the emergency department will have CDT levels measured as part of the study. Researchers will then collect and analyze clinical data, including mortality, duration of mechanical ventilation, delirium, ICU length of stay, renal replacement therapy, and ICU readmission rates, during hospitalization and follow-up.

Study Type

OBSERVATIONAL

Enrollment

800

Conditions

Intensive Care (ICU)Critical Illness Alcohol Misuse

Interventions

Carbohydrate-deficient transferrin (CDT) measurement is performed at ICU admission as an objective biomarker of sustained hazardous alcohol consumption during the previous 1-3 weeks. CDT values are obtained from routinely collected blood samples in adult non-traumatic ICU patients admitted via the emergency department. The study is purely observational and does not involve administration of a therapeutic intervention or changes to standard clinical care. CDT levels are analyzed in relation to outcomes including 30-day mortality, ICU length of stay, mechanical ventilation, delirium, renal replacement therapy, and ICU readmission.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * all patients ≥ 18 admitted to the Department of Emergency Medicine and subsequently transferred to an in-house intensive care unit (ICU) Exclusion Criteria: * Patients transferred to other hospital departments prior to completion of intensive care * Patients admitted directly to the ICU without passing the ED * Patients admitted to intermediate care units * Patients with pre-existing or newly diagnosed hepatic cirrhosis * Patients with known or obvious pregnancy will be excluded. * Patients with no vascular access

Outcomes

Primary Outcomes

The primary outcome of the study is 30-day all-cause mortality in ICU patients.

30-day all-cause mortality is defined as death from any cause occurring within 30 days after ICU admission. Mortality status will be assessed using patient medical records and, if unavailable, through the Austrian "Zentrales Personenstandsregister" (Central Civil Status Register), which documents registered deaths. Outcomes will be compared between patients with elevated and non-elevated carbohydrate-deficient transferrin (CDT) levels measured at ICU admission.

Time frame: From ICU admission to 30 days after ICU admission

Secondary Outcomes

In-hospital mortality

Death from any cause occurring during the index hospital stay.

Time frame: From hospital admission to hospital discharge evaluated 6 Months after study inclusion

ICU length of stay

Duration of stay in the intensive care unit, measured in days from ICU admission to ICU discharge.

Time frame: From ICU admission to ICU discharge evaluated 6 Months after study inclusion

Duration of mechanical ventilation

Total duration of mechanical ventilation during the ICU stay, measured in hours or days.

Time frame: From initiation of mechanical ventilation to successful discontinuation during ICU stay evaluated 6 Months after study inclusion

Illness severity score

Severity of illness assessed using TISS(-A), with a higher score signaling higher severity

Time frame: Evaluated from the documentation 6 Months after study inclusion

Illness severity score

Severity of illness assessed using APACHE II , with a higher score signaling higher severity

Time frame: Evaluated from the documentation 6 Months after study inclusion

Illness severity score

Severity of illness assessed using SAPS II, with a higher score signaling higher severity

Time frame: Evaluated from the documentation 6 Months after study inclusion

Illness severity score

Severity of illness assessed using SOFA scores, with a higher score signaling higher severity

Time frame: Evaluated from the documentation 6 Months after study inclusion

Intensive Care Outcome Prediction Using Admission Carbohydrate-deficient Transferrin

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts