Ultra-processed food (UPF) intake has been related to negative health effects and incresed energy intake in previous intervention studies. Thus, previous studies have seen weight gain from higher UPF intake which obscures the potentital to see effects on cardiometabolic biomarkers, independent of weight changes. The overall aim of this project is to study the causal effects of a high UPF diet, compared to a nutrient-matched low UPF diet, on appetite and cardiometabolic health in a weight-stable context.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
40
Diet high in Ultra-processed food (\>80 % of total energy intake)
Diet low in Ultra-processed food (\<20 % of total energy intake)
University of Gothenburg
Gothenburg, Sweden
Leptin
Time frame: Change from baseline to 6 weeks
ApoB
Apolipoprotein B
Time frame: Change from baseline to 6 weeks
Leptin
Time frame: Change from baseline to 2 weeks
ApoB
Apolipoprotein B
Time frame: Change from baseline to 2 weeks
Ghrelin, PYY, cholecystokinin, insulin
Other appetite-regulating hormones
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Blood lipid profile
ApoA1, LDL, HDL, VLDL, total cholesterol, triglycerides, Lp(a)
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Body weight
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Body composition
Fat mass and fat-free mass
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Blood pressure
Diastolic and systolic blood pressure
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Biomarkers of ultra-processed food intake
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Measured in blood and urine
Time frame: At 2 weeks and at 6 weeks
Gut microbiome
Change in gut microbial composition and diversity (alpha- and beta)
Time frame: At 2 weeks and 6 weeks
Glucose
Glucose, measured by continuous blood glucose monitoring
Time frame: Continuous during the first 2 weeks
Energy intake
Ad libitum energy intake at standardized test meal
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Subjective appetite
Self-rated appetite before and after a standasized test meal
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks
Food cravings and eating behavior
Control of Eating Questionnaire, Three Factor Eating Questionnaire, Power of Food Scale
Time frame: Change from baseline to 2 weeks and from baseline to 6 weeks